FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AlkUAS.DN
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General Information
Symbol
Dmel\AlkUAS.DN
Species
D. melanogaster
Name
FlyBase ID
FBal0152790
Feature type
allele
Associated gene
Dmel\Alk
Associated Insertion(s)
Carried in Construct
P{UAS-Alk.DN}
Also Known As
UAS-AlkDN
Key Links
Transgenic product class
dominant_negative_variant
(Lee et al., 2003)
inframe_deletion
(Lee et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Lee et al., 2003)
inframe_deletion
(Lee et al., 2003)
Mutagen
in vitro construct
(Lee et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Alk.DN}
Cytology
Description

Expression of amino acids 1-1143 of Alk is under the control of UASt sequences.

(Lee et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Alk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  tauopathy
      modeled by Hsap\MAPTGMR.Ex.PJ
      (Park et al., 2021)
      modeled by Hsap\MAPTUAS.cWa
      (Park et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      muscle founder cell & visceral muscle primordium, with Scer\GAL4twi.2PE

      (Lee et al., 2003)
      Detailed Description
      Statement
      Reference

      Marker analysis suggests that AlkScer\UAS.DN; Scer\GAL4twi.2PE embryos lack visceral muscle founder cells.

      (Lee et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      AlkUAS.DN/Scer\GAL4GMR.PU is a suppressor of eye phenotype of Hsap\MAPTGMR.Ex.PJ

      (Park et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AlkScer\UAS.DN
      AlkUAS.DN
      Name Synonyms
      Secondary FlyBase IDs
        References (3)