FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Alk8
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General Information
Symbol
Dmel\Alk8
Species
D. melanogaster
Name
FlyBase ID
FBal0157357
Feature type
allele
Associated gene
Dmel\Alk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Loren et al., 2003)
Progenitor genotype
Cytology
Description

Encodes a protein truncated at the C-terminal end of the trans-membrane domain.

(Englund et al., 2003)

Carries a splice-donor site mutation that is predicted to generate a Alk protein that is truncated after the transmembrane domain.

(Loren et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:16,632,018..16,632,018 [-]
Comment:

An unspecified mutation in the splice donor site. The splice site mutation has been arbitrarily mapped by a FlyBase curator to the first base of the splice donor site.

(Loren et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurofibromatosis
      modeled by Nf1E2
      (Moscato et al., 2020, Walker et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      axon & photoreceptor cell R8 | somatic clone

      (Bazigou et al., 2007)
      Detailed Description
      Statement
      Reference

      The central nervous system of Alk8 mutants appears morphologically normal in terms of segmental nerve branching and segmental muscle patterning. Neuropil synaptic differentiation appears normal in these mutants, with comparable labeling intensity, density and distribution of presynaptic and postsynaptic labels.

      Alk8 mutant neuromuscular junctions appear correctly and stereotypically formed and elaborated, with no examples of muscle innervation failure or synaptic targeting errors. Mutant presynaptic active zones appear normally formed and with wild-type size.

      (Rohrbough and Broadie, 2010)

      R8 axons in mosaic adults with Alk8 in the lamina target neurons exhibit thickened terminals and fasciculate with R7/R8 axons in adjacent columns or fail to extend into the medulla neuropil.

      (Bazigou et al., 2007)

      Alk8/+ animals have no observable mutant phenotype.

      (Loren et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Alk8 is a suppressor of decreased body size | pupal stage phenotype of Nf1E2

      (Walker et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: P{neoFRT}42D chromosome.

      (Loren et al., 2003)

      Selected as: a mutant that fails to complement the Df(2R)Alk-21 deficiency.

      (Loren et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Alk8
      (Moscato et al., 2020, Rohrbough and Broadie, 2010, Bazigou et al., 2007, Bazigou et al., 2007, Loren et al., 2003)
      dAlk8
      (Walker et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)