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General Information
Symbol
Dmel\Alk8
Species
D. melanogaster
Name
FlyBase ID
FBal0157357
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Splice donor mutation resulting in truncation just after the transmembrane domain.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Encodes a protein truncated at the C-terminal end of the trans-membrane domain.

Carries a splice-donor site mutation that is predicted to generate a Alk protein that is truncated after the transmembrane domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

axon & photoreceptor cell R8 | somatic clone

Detailed Description
Statement
Reference

The central nervous system of Alk8 mutants appears morphologically normal in terms of segmental nerve branching and segmental muscle patterning. Neuropil synaptic differentiation appears normal in these mutants, with comparable labeling intensity, density and distribution of presynaptic and postsynaptic labels.

Alk8 mutant neuromuscular junctions appear correctly and stereotypically formed and elaborated, with no examples of muscle innervation failure or synaptic targeting errors. Mutant presynaptic active zones appear normally formed and with wild-type size.

R8 axons in mosaic adults with Alk8 in the lamina target neurons exhibit thickened terminals and fasciculate with R7/R8 axons in adjacent columns or fail to extend into the medulla neuropil.

Alk8/+ animals have no observable mutant phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Alk8 is a suppressor of decreased body size | pupal stage phenotype of Nf1E2

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Induced on: P{neoFRT}42D chromosome.

Selected as: a mutant that fails to complement the Df(2R)Alk-21 deficiency.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)