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Citation
Kusano, K., Johnson-Schlitz, D.M., Engels, W.R. (2001). Sterility of Drosophila with mutations in the Bloom syndrome gene-complementation by Ku70.  Science 291(5513): 2600--2602.
FlyBase ID
FBrf0135945
Publication Type
Research paper
Abstract

The Drosophila Dmblm locus is a homolog of the human Bloom syndrome gene, which encodes a helicase of the RECQ family. We show that Dmblm is identical to mus309, a locus originally identified in a mutagen-sensitivity screen. One mus309 allele, which carries a stop codon between two of the helicase motifs, causes partial male sterility and complete female sterility. Mutant males produce an excess of XY sperm and nullo sperm, consistent with a high frequency of nondisjunction and/or chromosome loss. These phenotypes of mus309 suggest that Dmblm functions in DNA double-strand break repair. The mutant Dmblm phenotypes were partially rescued by an extra copy of the DNA repair gene Ku70, indicating that the two genes functionally interact in vivo.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Aberrations (4)
    Alleles (10)
    Genes (9)
    Human Disease Models (1)
    Insertions (6)
    Transgenic Constructs (3)