W922term | Blm-PA
G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.
The rate of spontaneous mitotic crossovers in BlmN1/BlmD2 Fancm0693/Df(3R)ED6058 males is not significantly different from that in Fancm0693/Df(3R)ED6058 males, but is significantly lower than in BlmN1/BlmD2 males.
mus309N1/mus309D2 mus312D1/mus312Z1973 double mutant larvae have small brains, lack imaginal discs and have a reduced number of salivary gland imaginal ring cells. The nuclei of the remaining salivary gland imaginal ring cells appear larger than normal. Mitotic neuroblasts in these larvae show extreme genome instability; no mitotic nuclei with completely intact chromosomes are detected and approximately one-third show polyploidy.
Genunspecified/Df(3L)Exel6103 mus309N1/mus309D2 spn-Aunspecified triple mutant larvae have small brain and generally lack imaginal discs (although very small rudimentary discs are occasionally visible). Salivary gland imaginal ring cells are reduced in number and have enlarged nuclei. Mitotic neuroblasts have numerous chromosome breaks.
The addition of spn-Aunspecified suppresses the the chromosome breakage and polyploidy phenotypes seen in mitotic neuroblasts of mus309N1/mus309D2 mus312D1/mus312Z1973 larvae, and also suppresses the defects in the salivary gland imaginal ring cells seen in the mus309N1/mus309D2 mus312D1/mus312Z1973 double mutants. However, addition of spn-Aunspecified does not suppress the pupal lethality, small brains and lack of imaginal discs seen in the mus309N1/mus309D2 mus312D1/mus312Z1973 double mutants.
mus312D1/mus312Z1973, mus309D2/mus309N1 double mutants are inviable, dying after pupariation. Third-instar larvae have melanotic tumors and lack larval imaginal discs. Larval brains of double mutants are greatly reduced in size.
okr17-11/okrA19-10 mus309D2/mus309D3 double mutants show a synergistic effect on sensitivity to X rays; the sensitivity is increased 40 fold compared to wild-type in double mutants. mus309D2/mus309D3 mutants are slightly sensitive to methyl methanesulfonate (MMS). okr17-11/okrA19-10 mus309D2/mus309D3 double mutants do not show a synergistic effect on sensitivity to MMS.