FlyBase Allele Report: Dmel\slx1[F93I]

General Information

Symbol

Dmel\slx1^F93I

Species

D. melanogaster

Name

FlyBase ID

FBal0264507

Feature type

allele

Associated gene

Dmel\slx1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: F93I.

(Andersen et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:4,643,807..4,643,807 [+]

Nucleotide change:

T4643807A

Amino acid change:

F93I | slx1-PB

Reported amino acid change:

F93I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Andersen et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

slx1^F93I/mus81^Nhe is a suppressor of abnormal mitotic cell cycle phenotype of Fancm⁰⁶⁹³/Df(3R)ED6058

(Kuo et al., 2014)

NOT Suppressor of

Statement

Reference

slx1^F93I is a non-suppressor of abnormal mitotic cell cycle phenotype of Fancm⁰⁶⁹³/Df(3R)ED6058

(Kuo et al., 2014)

slx1^F93I/mei-9^a is a non-suppressor of abnormal mitotic cell cycle phenotype of Fancm⁰⁶⁹³/Df(3R)ED6058

(Kuo et al., 2014)

Other

Statement

Reference

Fancm⁰⁶⁹³/Df(3R)ED6058, slx1^F93I has viable phenotype

(Kuo et al., 2014)

Fancm⁰⁶⁹³/Df(3R)ED6058, mei-9^a, slx1^F93I has viable phenotype

(Kuo et al., 2014)

Fancm⁰⁶⁹³/Df(3R)ED6058, mus81^Nhe, slx1^F93I has viable phenotype

(Kuo et al., 2014)

Blm^N1/Blm^D2, slx1^F93I has lethal - all die during pupal stage phenotype

(Kuo et al., 2014)

Blm^N1/Blm^D2, slx1^F93I has lethal | pupal stage phenotype

(Andersen et al., 2011)

Phenotype Manifest In

Other

Statement

Reference

Blm^N1/Blm^D2, slx1^F93I has imaginal disc | larval stage phenotype

(Andersen et al., 2011)

Blm^N1/Blm^D2, slx1^F93I has larval neuroblast | larval stage phenotype

(Andersen et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The rate of spontaneous mitotic crossovers in Fancm⁰⁶⁹³/Df(3R)ED6058 males is not affected if animals are also mutant for slx1^F93I, or if these animals are also mutant for both slx1^F93I and mei-9^a. However crossovers are nearly absent in Fancm⁰⁶⁹³/Df(3R)ED6058 animals that are also mutant for both mus81^Nhe and slx1^F93I.

(Kuo et al., 2014)

mus309^N1/mus309^D2 slx1^F93I double mutant animals die as early pupae, larvae lack imaginal discs and larval neuroblasts are frequently polyploid.

(Andersen et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

slx1^F93I

(Carvajal-Garcia et al., 2021, Kuo et al., 2014, Andersen et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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