FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\cpa
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General Information
Symbol
Dmel\cpa
Species
D. melanogaster
Name
capping protein alpha
Annotation Symbol
CG10540
Feature Type
protein_coding_gene
FlyBase ID
FBgn0289712
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
capping protein alpha (cpa) encodes an actin-binding protein that, along with the product of cpb, binds to the fast growing ends of actin filaments to restrict the addition or loss of actin monomers. It limits the nuclear translocation of the Hippo pathway mediator encoded by yki and restricts JNK signaling. It maintains epithelial integrity and controls the balance between proliferation and apoptosis in the wing imaginal disc. It plays important roles during oogenesis, as well as maintaining neuronal homeostasis. [Date last reviewed: 2018-10-18] (FlyBase Gene Snapshot)
All Summaries
Also Known As

miro, Capping Protein, Capping protein α, Cap1

Key Links
Genomic Location
Cytogenetic map
57B16-57B16
Sequence location
Recombination map
2-92
RefSeq locus
NT_033778 REGION:21057787..21059883
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein heterodimerization activity
inferred from physical interaction with FLYBASE:cpb; FB:FBgn0011570
(Amândio et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables actin filament binding
inferred from biological aspect of ancestor with PANTHER:PTN000068943
(GO Reference Genome Project, 2011-)
Biological Process (12 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from mutant phenotype
(Delalle et al., 2005)
involved_in actin filament organization
inferred from mutant phenotype
(Sander et al., 2013)
involved_in barbed-end actin filament capping
inferred from mutant phenotype
(Amândio et al., 2014)
involved_in germarium-derived oocyte fate determination
inferred from mutant phenotype
(Gates et al., 2009)
involved_in negative regulation of actin filament polymerization
inferred from mutant phenotype
(Janody and Treisman, 2006)
involved_in negative regulation of filopodium assembly
inferred from mutant phenotype
(Gonçalves-Pimentel et al., 2011)
involved_in negative regulation of JNK cascade
inferred from genetic interaction with FLYBASE:cpb; FB:FBgn0011570
(Fernández et al., 2014)
involved_in nuclear envelope budding
inferred from mutant phenotype
(Verboon et al., 2020)
involved_in positive regulation of filopodium assembly
inferred from direct assay
(Bischoff et al., 2013)
involved_in regulation of filopodium assembly
inferred from mutant phenotype
(Sander et al., 2013)
involved_in regulation of lamellipodium assembly
inferred from mutant phenotype
(Iwasa and Mullins, 2007)
involved_in wing disc development
inferred from mutant phenotype
(Janody and Treisman, 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN000068943
(GO Reference Genome Project, 2011-)
involved_in barbed-end actin filament capping
inferred from electronic annotation with InterPro:IPR002189
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000068943
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
colocalizes_with adherens junction
inferred from direct assay
(Amândio et al., 2014)
located_in apical plasma membrane
inferred from direct assay
(Janody and Treisman, 2006)
part_of F-actin capping protein complex
inferred from direct assay
(Amândio et al., 2014)
is_active_in Z disc
inferred from direct assay
(Deng et al., 2021)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cortical cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000068943
(GO Reference Genome Project, 2011-)
part_of F-actin capping protein complex
inferred from electronic annotation with InterPro:IPR002189
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000068943
(GO Reference Genome Project, 2011-)
part_of WASH complex
inferred from sequence or structural similarity with UniProtKB:P52907
(Derivery and Gautreau, 2010)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the F-actin-capping protein alpha subunit family. (Q9W2N0)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
capping protein alpha (cpa) encodes an actin-binding protein that, along with the product of cpb, binds to the fast growing ends of actin filaments to restrict the addition or loss of actin monomers. It limits the nuclear translocation of the Hippo pathway mediator encoded by yki and restricts JNK signaling. It maintains epithelial integrity and controls the balance between proliferation and apoptosis in the wing imaginal disc. It plays important roles during oogenesis, as well as maintaining neuronal homeostasis. [Date last reviewed: 2018-10-18]
Gene Group (FlyBase)
DYNACTIN COMPLEX -
Dynactin is a large 1.2 MDa multisubunit protein complex that associates with the cytoplasmic dynein complex to drive microtubule-based transport. (Adapted from PMID:15473859 and PMID:25751425).
F-ACTIN CAPPING PROTEIN COMPLEX -
The F-actin capping protein complex is a heterodimer which regulates actin polymerization. The complex binds to the plus (barbed) end of actin filaments and blocks the exchange of actin monomers. (Adapted from FBrf0213674 and FBrf0224864).
Protein Function (UniProtKB)
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
(UniProt, Q9W2N0)
Summary (Interactive Fly)

regulates nonbundle actin filament assembly during bristle development - acts upstream of the Hippo pathway and functions as a tumor suppressor, antagonized by Enabled, maintains epithelial integrity and prevents JNK-mediated apoptosis, functions in oocyte determination

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\cpa for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W2N0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
cpa-RA
FBtr0071532
NM_137695
1918
286
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
cpa-PA
FBpp0071461
32.8
286
5.80
Q9W2N0
NP_611539
AAF46660
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.

(UniProt, Q9W2N0)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cpa using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with adherens junction
inferred from direct assay
(Amândio et al., 2014)
located_in apical plasma membrane
inferred from direct assay
(Janody and Treisman, 2006)
part_of F-actin capping protein complex
inferred from direct assay
(Amândio et al., 2014)
is_active_in Z disc
inferred from direct assay
(Deng et al., 2021)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\cpa in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of cpa
Transgenic constructs containing regulatory region of cpa
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2R)Exel6072
(Ryder, 2004.4.26)
Df(2R)Pu-D17
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | partially | somatic clone
lethal
lethal (with cpa43D)
lethal (with cpa69E)
lethal (with cpa107E)
lethal (with cpascrd1)
lethal (with cpascrd2)
lethal | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage
lethal - all die during first instar larval stage (with cpa69E)
lethal - all die during first instar larval stage (with cpa107E)
lethal - all die during first instar larval stage | recessive
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Other Phenotypes
Allele
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal size | larval stage, with Scer\GAL4hh-Gal4
decreased cell death, with Scer\GAL4nub-AC-62
increased cell death | heat sensitive, with Scer\GAL4sd-SG29.1
increased cell growth rate, with Scer\GAL4nub-AC-62
increased occurrence of cell division | larval stage, with Scer\GAL4hh-Gal4
neoplasia | larval stage, with Scer\GAL4hh.PU
some die during pupal stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
some die during pupal stage, with Scer\GAL4pnr-MD237
visible | recessive | somatic clone
visible | somatic clone
Phenotype manifest in
Allele
actin cytoskeleton, with Scer\GAL4Hml.Δ
actin cytoskeleton & eye disc | somatic clone
cytoneme | larval stage, with Scer\GAL4hh-Gal4
egg chamber | germline clone
eye, with Scer\GAL4αTub84B.PL, cpa43D/cpa107E
eye, with Scer\GAL4αTub84B.PL, cpa69E/cpa43D
eye (with cpa43D), with Scer\GAL4αTub84B.PL, cpaUAS.Tag:HA
eye (with cpa69E), with Scer\GAL4αTub84B.PL, cpaUAS.Tag:HA
eye (with cpa107E), with Scer\GAL4αTub84B.PL, cpaUAS.Tag:HA
eye | somatic clone
filopodium | increased number
follicle cell | somatic clone
macrochaeta, with Scer\GAL4αTub84B.PL, cpa43D/cpa107E
macrochaeta, with Scer\GAL4αTub84B.PL, cpa69E/cpa43D
macrochaeta (with cpa43D), with Scer\GAL4αTub84B.PL, cpaUAS.Tag:HA
macrochaeta (with cpa69E), with Scer\GAL4αTub84B.PL, cpaUAS.Tag:HA
macrochaeta (with cpa107E), with Scer\GAL4αTub84B.PL, cpaUAS.Tag:HA
oocyte | germline clone
oocyte nucleus | germline clone
wing, with Scer\GAL4αTub84B.PL, cpa43D/cpa107E
wing, with Scer\GAL4αTub84B.PL, cpa69E/cpa43D
wing (with cpa43D), with Scer\GAL4αTub84B.PL, cpaUAS.Tag:HA
wing (with cpa69E), with Scer\GAL4αTub84B.PL, cpaUAS.Tag:HA
wing (with cpa107E), with Scer\GAL4αTub84B.PL, cpaUAS.Tag:HA
wing disc, with Scer\GAL4ap-md544
wing disc, with Scer\GAL4hh.PU
wing disc, with Scer\GAL4hh-Gal4
wing disc, with Scer\GAL4nub-AC-62
wing disc, with Scer\GAL4sd-SG29.1
wing disc | somatic clone
wing disc posterior compartment, with Scer\GAL4hh-Gal4
wing disc posterior compartment | heat sensitive, with Scer\GAL4hh-Gal4, Scer\GAL80ts.αTub84B
wing hinge primordium, with Scer\GAL4hh.PU
wing hinge primordium, with Scer\GAL4sd-SG29.1
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\CAPZA1
14 of 14
Yes
Yes
2  
Hsap\CAPZA2
13 of 14
No
Yes
 
4  
Hsap\CAPZA3
6 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Capza1
14 of 14
Yes
Yes
Rnor\Capza2
12 of 14
No
Yes
Rnor\Capza3
6 of 14
No
Yes
Rnor\RGD1563947
2 of 14
No
Yes
Mus musculus (laboratory mouse) (4)
Mmus\Capza1
13 of 14
Yes
Yes
Mmus\Capza2
13 of 14
Yes
Yes
Mmus\4933400A11Rik
11 of 14
No
Yes
Mmus\Capza3
6 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\capza1
11 of 13
Yes
Yes
Xtro\capza2
7 of 13
No
Yes
Danio rerio (Zebrafish) (2)
Drer\capza1a
14 of 14
Yes
Yes
Drer\capza1b
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\cap-1
14 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP006141
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\CPA
13 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CAP1
12 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\acp1
11 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:cpa. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CAPZA1; capping actin protein of muscle Z-line subunit alpha 1
14 of 14
601580
       
      CAPZA2; capping actin protein of muscle Z-line subunit alpha 2
      13 of 14
      CAPPING PROTEIN, ALPHA-2; CAPZA2
           
          CAPZA3; capping actin protein of muscle Z-line subunit alpha 3
          6 of 14
          608722
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Dmel gene
              Ortholog showing functional complementation
              Supporting References
              cpa
              Hsap\CAPZA2
              (Huang et al., 2020)
              Interactions
              Summary of Physical Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please see the Physical Interaction reports below for full details
              protein-protein
              Physical Interaction
              Assay
              References
              cpa - Act57B
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - Akt
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              cpa - Arp2
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - Arp3
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - Arpc1
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - Arpc2
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - Arpc3A
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - Arpc4
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - Arpc5
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - CG8578
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - DCTN2-p50
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - Dsor1
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              cpa - LRR
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - Ndc80
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Przewloka et al., 2007)
              cpa - Rheb
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              cpa - S6k
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              cpa - Swip-1
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - cindr
              anti bait coimmunoprecipitation, peptide massfingerprinting
              (Johnson et al., 2008)
              cpa - cpb
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - didum
              experimental knowledge based
              (Guruharsha et al., 2011)
              cpa - dos
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              cpa - osk
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Hurd et al., 2016)
              cpa - sima
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              cpa
              suppressible
              Diap1
              (Janody and Treisman, 2006)
              cpa
              enhanceable
              vg
              (Janody and Treisman, 2006)
              cpa
              suppressible
              yki
              (Sansores-Garcia et al., 2011)
              cpb|cpa
              suppressible
              Zyx
              (Gaspar et al., 2015)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              cindr
              enhanceable
              cpa
              (Johnson et al., 2008)
              Csk
              enhanceable
              cpa
              (Rudrapatna et al., 2014)
              Src64B
              enhanceable
              cpa
              (Fernández et al., 2014)
              Src64B
              enhanceable
              cpb|cpa
              (Fernández et al., 2014)
              Src64B
              suppressible
              cpb|cpa
              (Fernández et al., 2014)
              Zyx
              suppressible
              cpb|cpa
              (Gaspar et al., 2015)
              Zyx
              enhanceable
              cpb|cpa
              (Gaspar et al., 2015)
              External Data
              Subunit Structure (UniProtKB)
              Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.
              (UniProt, Q9W2N0 )
              Linkouts
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2R
              Recombination map
              2-92
              Cytogenetic map
              57B16-57B16
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              57B16-57B16
              Limits computationally determined from genome sequence between P{EP}grauEP688&P{PZ}shg10469 and P{PZ}king-tubby02821&P{lacW}Xbp1k13803
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              57B13-57B14
              (determined by in situ hybridisation)
              (Spradling et al., 1999)
              57B13-57B14
              (BDGP Project Members, 1994-1999)
              Experimentally Determined Recombination Data
              Location

              2-92

              (FlyBase, 2016)

              2-99.7

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (11)
              Genomic Clones (10)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (67)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Schmidt et al., 2021, Amândio et al., 2014)
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      cpa is required to maintain vg-expressing cells in the wing disc epithelium.

                      (Janody and Treisman, 2006)

                      S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

                      (Stroschein-Stevenson et al., 2006)

                      Mutant clones in the imaginal discs accumulate actin filaments all around the cell cortex. Mutant clones in the eye disc cause photoreceptor nuclei to drop out of the eye disc epithelium and move towards and through the optic stalk. Mutant clones are not recovered in the epithelium of the wing pouch, although they can be recovered in the epithelium of the remainder of the wing disc.

                      (Janody et al., 2005)

                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                      (Kiger et al., 2003)

                      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: increased or polarized (uneven) accumulation of F-actin.

                      (Kiger et al., 2003)
                      Relationship to Other Genes
                      Source for database merge of

                      Source for merge of: cpa l(2)07206

                      (Steinmetz et al., 2023)
                      Additional comments

                      l(2)07206 may correspond to cpa: the P{PZ}l(2)0720607206 insertion maps within the transcription unit.

                      (Gene Disruption Project members, 2015.10.8)
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: CG10540 miro

                      (Janody, 2005.3.2)

                      Source for identity of: cpa CG10540

                      (Delalle et al., 2005)
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (22)
                      Reported As
                      Symbol Synonym
                      CG10540
                      (Trivedi et al., 2020, Kolkhof et al., 2017, Hurd et al., 2016, Álvarez-Fernández et al., 2015, Balakrishnan et al., 2015, Llamusi et al., 2013, Azad et al., 2012, Murray et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2008, Bakal et al., 2007, Przewloka et al., 2007, Stroschein-Stevenson et al., 2006, Delalle et al., 2005, Liebl and Featherstone, 2005, Eckley and Schroer, 2003, Giot et al., 2003, Kiger et al., 2003, Stark et al., 2003, Goldstein and Gunawardena, 2000)
                      Cap1
                      (Kollmar, 2015.9.21, Hammesfahr and Kollmar, 2012)
                      CapZα
                      (Derivery and Gautreau, 2010)
                      Cp&abg;
                      (Gou et al., 2020)
                      CpA
                      (Verboon et al., 2020)
                      Cpa
                      (Deng et al., 2021, Schmidt et al., 2021, Agbu et al., 2020, González-Méndez et al., 2017, Richardson and Portela, 2017, Lucas et al., 2013, Rebelo and Janody, 2007)
                      cpa
                      (Akagi et al., 2025, Guo et al., 2024, Lee et al., 2024, Li et al., 2024, Chan et al., 2023, Nieken et al., 2023, Steinmetz et al., 2023, Ecovoiu et al., 2022, Chougule et al., 2020, Deng et al., 2020, Huang et al., 2020, Skouloudaki et al., 2020, Zhao et al., 2020, Myat et al., 2019, Yuan et al., 2019, Forest et al., 2018, Butzlaff et al., 2015, Gaspar et al., 2015, Amândio et al., 2014, Fernández et al., 2014, Li et al., 2014, Rudrapatna et al., 2014, Valanne, 2014, Beckett et al., 2013, Kwon et al., 2013, Sander et al., 2013, Azad et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Lloyd et al., 2012, Fernández et al., 2011, Friedman et al., 2011, Gonçalves-Pimentel et al., 2011, Rohn et al., 2011, Tiwari et al., 2011, Ulvila et al., 2011, Blanco et al., 2010, Gates et al., 2009, Johnson et al., 2008, Janody and Treisman, 2006)
                      cpα
                      (Álvarez-Fernández et al., 2015)
                      l(2)07206
                      miro
                      (Janody, 2005.3.2, Janody et al., 2005)
                      scrd
                      (Delalle et al., 2005)
                      Name Synonyms
                      Capping Protein
                      (Serio et al., 2010, Nowotarski et al., 2008)
                      Capping protein alpha
                      (Rebelo and Janody, 2007)
                      Capping protein α
                      (Iwasa and Mullins, 2007, Janody and Treisman, 2006)
                      Capping α
                      (D'Ambrosio and Vale, 2010)
                      actin capping protein
                      (Gou et al., 2020)
                      actin-capping protein
                      (van Soldt and Cardoso, 2020)
                      capping protein A
                      (Li et al., 2014)
                      capping protein alpha
                      (Rudrapatna et al., 2014, Cammarato et al., 2011, Johnson et al., 2008, Delalle et al., 2005)
                      capping protein α
                      (Amândio et al., 2014)
                      capping proteinα
                      (Gates et al., 2009)
                      lethal (2) 07206
                      Secondary FlyBase IDs
                      • FBgn0034577
                      • FBgn0010637
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 31 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      References (133)