FB2026_02 , released June 18, 2026
Gene Group: NON-RECEPTOR TYROSINE KINASES
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General Information
Name
NON-RECEPTOR TYROSINE KINASES
Species
D. melanogaster
Symbol
NON-RTK
FlyBase ID
FBgg0000245
Date last reviewed
2015-03-25
Number of members
12
Description
Description
Non-Receptor Tyrosine kinases (nRTK) are cytoplasmic protein kinases that specifically phosphorylate tyrosine residues. nRTKs are involved in signalling cascades and possess targeting domains such as SH2 domains. (Adapted from FBrf0132098).
Notes on Group

hop possesses a functional and a pseudokinase domain (FBrf0209106).

Wee1 is a tyrosine kinase, but its sequence is more similar to serine/threonine kinases (PMID:15837193).

Source Material
The NON-RECEPTOR TYROSINE KINASES Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000, and Campbell et al., 1995 .
Key Gene Ontology (GO) terms
Molecular Function
non-membrane spanning protein tyrosine kinase activity
Biological Process
protein phosphorylation
Cellular Component
Enzymatic activity
Enzyme name (EC)
non-specific protein-tyrosine kinase (2.7.10.2)
Related Gene Groups
Parent group(s)
TYROSINE KINASES
Members (12)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
NON-RTK
NON-RECEPTOR TYROSINE KINASES
Non-Receptor Y kinases
Cytosolic tyrosine kinases
Cytosolic Y kinases
CTK
nRTK
Secondary FlyBase ID(s)
References (5)