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Citation
Wang, X.H., Aliyari, R., Li, W.X., Li, H.W., Kim, K., Carthew, R., Atkinson, P., Ding, S.W. (2006). RNA interference directs innate immunity against viruses in adult Drosophila.  Science 312(5772): 452--454.
FlyBase ID
FBrf0190618
Publication Type
Research paper
Abstract

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.

PubMed ID
PubMed Central ID
PMC1509097 (PMC) (EuropePMC)
Related Publication(s)
Review

Flies dice up RNA viruses.
Budde, 2006, Cell 125(5): 819 [FBrf0198689]

Note

Innate immune defense through RNA interference.
Fritz et al., 2006, Sci. STKE 2006(339): pe27 [FBrf0194359]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075 1095-9203
    Data From Reference
    Alleles (3)
    Genes (3)