FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
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Kaufman, T. (2010.8.13). Centrin & CG17493. 
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FBrf0211541
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Personal communication to FlyBase
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Dear FlyBase
In my usual stumbling through the highways and byways of FlyBase I came across the following:
We have a lovely gene report at  http://flybase.org/reports/FBgn0041762.html for a gene named centrin.
The basis of that report is i believe a set of papers that report the staining of fly cells/embryos with an antibody to human Centrin:
Bettencourt-Dias et al., 2005, Curr. Biol. 15(24): 2199--2207
SAK/PLK4 is required for centriole duplication and flagella development. <up>FBrf0189998</up>
Bucciarelli et al., 2003, J. Cell Biol. 160(7): 993--999
Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. <up>FBrf0159033</up>
Riparbelli et al., 2002, J. Cell Sci. 115(5): 913--922
A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila. <up>FBrf0144956</up>
de Carcer et al., 2001, EMBO J. 20(11): 2878--2884
Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability. <up>FBrf0136861</up>
Callaini et al., 1999, Biol. Cell 91: 355--366
Centrosome inheritance in insects: Fertilization and parthenogenesis. <up>FBrf0129225</up>
Further perusal of other gene reports by somewhat tortured paths that I won't bore you with leads me to CG17493 (http://flybase.org/reports/FBgn0040010.html)
In this report under Molecular function one finds:  "inferred from sequence or structural similarity with mouse Cetn2" and under orthologs:   "ENSP00000359300  Homo sapiens (human)", which is linked to the Human CENT2-001 Ensembl report.
Based on BLAST and protein alignments I'm pretty sure this is the Fly ortholog of centrin encoding the fly version of Centrin.  Vertebrates having 2 genes our beloved fly only one.
I propose that either the two reports be merged or that they point to one another.  
--
Thom Kaufman
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