FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Recombinant Construct: P{UAS-hATXN3.fl.SCA3.C14A.UbS2-mild}
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General Information
Symbol
P{UAS-hATXN3.fl.SCA3.C14A.UbS2-mild}
FlyBase ID
FBtp0117492
Feature type
transgenic_transposable_element
Component Allele(s)
Hsap\ATXN3C14A.UbS2-mild.fl.SCA3.UAS
Size
Expression Data
Associated insertion(s)
1 available
Molecular map
Description and Uses
Construct components
Component allele Hsap\ATXN3C14A.UbS2-mild.fl.SCA3.UAS
Transgenic product class
missense_variant
(Sutton et al., 2017)
trinucleotide_repeat_expansion
(Sutton et al., 2017)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\ATXN3
Description

UAS regulatory sequences drive expression of a full-length, pathogenic form of Hsap\ATXN3 (has a polyglutamine repeat of 77-80 residues) with both a mutation that results in the protein being catalytically inactive (amino acid replacement C14A) and also a mutation in Ubiquitin-binding site 2 (UbS2) that mildly disrupts binding to Rad23 protein (amino acid replacement W87A).

(Sutton et al., 2017)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Ataxin-3(SCA3)-*C14A-UbS2*Mild
(Sutton et al., 2017)
P{UAS-hATXN3.fl.SCA3.C14A.UbS2-mild}
(FlyBase, 1992-)
Secondary FlyBase IDs
    References (3)