FlyBase Gene Report: Hsap\ATXN3

(Prange et al., 2024, Na et al., 2023, Swinter et al., 2023, Chakravorty et al., 2022, Cho et al., 2022, Chen et al., 2021, Ghosh et al., 2021, Kim et al., 2021, Nan et al., 2021, Oba et al., 2021, Tandon and Sarkar, 2021, Xie et al., 2021, Chakraborty et al., 2020, Han et al., 2020, Lohr et al., 2020, Park et al., 2020, Bason et al., 2019, Chen et al., 2019, Raj and Sarkar, 2019, Xu et al., 2019, Bardai et al., 2018, Sowa et al., 2018, Uechi et al., 2018, Chung et al., 2017, Raj and Sarkar, 2017, Frost et al., 2016, Babcock and Ganetzky, 2015, Lazarev et al., 2015, Saitoh et al., 2015, Tsou et al., 2015, Vinatier et al., 2015, Liman et al., 2014, Singh et al., 2014, Arribat et al., 2013, Cushman-Nick et al., 2013, Yi et al., 2013, Lee et al., 2011, Rana et al., 2010, Bilen and Bonini, 2007, Ryoo et al., 2007, Senoo-Matsuda et al., 2005, Bonini, 1999, Warrick et al., 1999)

CEC

(Sun et al., 2023, De Mena et al., 2017, Snijder et al., 2016, McGurk and Bonini, 2012, Voßfeldt et al., 2012)

model of neurodegenerative disease

CEA

(Burr et al., 2014, Tsou et al., 2013, Mallik and Lakhotia, 2009, Lam et al., 2008, Wong et al., 2008, Bilen et al., 2006, Huen and Chan, 2005, Kretzschmar et al., 2005, Lee et al., 2004, Gunawardena et al., 2003, Kanuka et al., 2003, Bonini, 2002, Chan et al., 2000, Warrick et al., 1998)

CEC

(Arya et al., 2010, Tonoki et al., 2009, Li et al., 2008)

model of autosomal dominant cerebellar ataxia

CEA

(Jia et al., 2013, Lessing and Bonini, 2008, Jung and Bonini, 2007, Ghosh and Feany, 2004, Perez et al., 1998)

CEC

(Lin et al., 2015, Martin-Lanneree et al., 2006, Mizutani et al., 2005)

Hsap\ATXN3^tr.Q46.UAS

model of autosomal dominant cerebellar ataxia

CEA

(Jung and Bonini, 2007)

Hsap\ATXN3^{fl.Q78.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Chung et al., 2017, Cushman-Nick et al., 2013, Lee et al., 2011)

model of autosomal dominant cerebellar ataxia

CEA

(Warrick et al., 2005)

CEC

(Boeddrich et al., 2006)

Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

model of neurodegenerative disease

CEA

(Burr et al., 2014, Bilen et al., 2006)

model of Machado-Joseph disease

CEA

(Chang et al., 2024, Zuniga et al., 2024, Nan et al., 2021, Chen et al., 2019, Wu et al., 2019, Chen et al., 2018, Vu et al., 2018, Yeh et al., 2018, Zhang et al., 2018, Fernius et al., 2017, Blount et al., 2014, Liman et al., 2014, Chan et al., 2011)

CEA with Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}

(Zhang et al., 2018)

model of autosomal dominant cerebellar ataxia

CEA

(Warrick et al., 2005)

CEC

(Boeddrich et al., 2006)

Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}

model of Machado-Joseph disease

CEA with Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Zhang et al., 2018)

Hsap\ATXN3^{fl.Q80.UIMmut.UAS.Tag:MYC}

model of Machado-Joseph disease

CEA

(Cushman-Nick et al., 2013)

Hsap\ATXN3^{fl.Q88.C14A.UAS.Tag:MYC}

model of Machado-Joseph disease

CEA

(Cushman-Nick et al., 2013)

Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}

model of Machado-Joseph disease

CEA

(Vinatier et al., 2015)

Hsap\ATXN3^{CAG89.UAS.Tag:HA,Tag:MYC,Tag:polyHis}

model of neurodegenerative disease

CEA

(Calpena et al., 2018)

Hsap\ATXN3^{UAS.Tag:polyHis}

model of neurodegenerative disease

CEA

(Burr et al., 2014)

Hsap\ATXN3^fl.SCA3.UAS

model of Machado-Joseph disease

CEA

(Ashraf et al., 2020, Johnson et al., 2020, Ristic et al., 2018, Sutton et al., 2017)

Hsap\ATXN3^{UbS2-mild.fl.SCA3.UAS}

model of Machado-Joseph disease

CEA

(Johnson et al., 2020, Sutton et al., 2017)

Hsap\ATXN3^{UbS2-strong.fl.SCA3.UAS}

model of Machado-Joseph disease

CEA

(Sutton et al., 2017)

Hsap\ATXN3^{C14A.fl.SCA3.UAS}

model of Machado-Joseph disease

CEA

(Prifti et al., 2022, Johnson et al., 2020, Sutton et al., 2017)

Hsap\ATXN3^{C14A.UbS2-mild.fl.SCA3.UAS}

model of Machado-Joseph disease

CEA

(Sutton et al., 2017)

Hsap\ATXN3^{Q80.C14A.UIMmut.UAS}

model of Machado-Joseph disease

CEA

(Cushman-Nick et al., 2013)

Hsap\ATXN3^{Q79.Δexon2.UAS}

model of Machado-Joseph disease

CEA

(Cushman-Nick et al., 2013)

Hsap\ATXN3^Q80.HNHH.UAS

model of Machado-Joseph disease

CEA

(Johnson et al., 2020)

Hsap\ATXN3^{tr.Q76.UAS.Tag:HA,Tag:MYC}

model of Machado-Joseph disease

CEA

(Kwon et al., 2018)

Hsap\ATXN3^{tr.Q70.cc0.UAS.Tag:HA,Tag:MYC}

model of Machado-Joseph disease

CEA

(Kwon et al., 2018)

Hsap\ATXN3^{polyQ78.QUAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Li et al., 2018)

Hsap\ATXN3^{80Q.1.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Prifti et al., 2022, Johnson et al., 2019)

Hsap\ATXN3^{80Q.2.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Johnson et al., 2019)

Hsap\ATXN3^{80Q.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Johnson et al., 2020)

Hsap\ATXN3^{Q80-only.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Johnson et al., 2020)

Hsap\ATXN3^{UIM1-2-Q80.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Johnson et al., 2020)

Hsap\ATXN3^{Q80-UIM3.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Johnson et al., 2020)

Hsap\ATXN3^{UIM1-2-Q80-UIM3.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Johnson et al., 2020)

Hsap\ATXN3^{80Q.UIMmut.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Johnson et al., 2020)

Hsap\ATXN3^{Q80.QUASp.Tag:V5}

model of Machado-Joseph disease

CEA

(Johnson et al., 2020)

Hsap\ATXN3^fl.Q77.UAS

model of Machado-Joseph disease

CEA

(Sujkowski et al., 2022, Johnson et al., 2021)

Hsap\ATXN3^fl.Q80.UAS

model of Machado-Joseph disease

CEA

(Johnson et al., 2021)

Hsap\ATXN3^{80Q-CAG.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Johnson et al., 2022)

Hsap\ATXN3^{80Q-CAGCAA.Met-Null.UAS}

model of Machado-Joseph disease

CEA

(Johnson et al., 2022)

Hsap\ATXN3^{80Q-CAG.Met-Null.UAS}

model of Machado-Joseph disease

CEA

(Johnson et al., 2022)

Hsap\ATXN3^{80Q.UbS1mut.UAS}

model of Machado-Joseph disease

CEA

(Prifti et al., 2022)

Hsap\ATXN3^{80Q.UIMmut.UbS1mut.UAS}

model of Machado-Joseph disease

CEA

(Prifti et al., 2022)

Hsap\ATXN3^{80Q-CAGCAA.UAS.cBa.Tag:HA}

model of Machado-Joseph disease

CEA

(Blount et al., 2023)

Hsap\ATXN3^{K117R.80Q-CAGCAA.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Blount et al., 2023)

Hsap\ATXN3^{Knull.80Q-CAGCAA.UAS.Tag:HA}

model of Machado-Joseph disease

CEA

(Blount et al., 2023)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 33 )

Allele

Disease

Interaction

References

Hsap\ATXN3^{ΔN'79QC.UAS.Tag:MYC}

model of neurodegenerative disease

is ameliorated by Mmus\Ube4b^UAS.Tag:FLAG

(Matsumoto et al., 2004)

Hsap\ATXN3^{tr.Q27.UAS.Tag:HA}

model of Machado-Joseph disease

is ameliorated by Itpr^KK100626

(Cho et al., 2022)

is ameliorated by Kap-α3^KK101268

(Cho et al., 2022)

is ameliorated by RyR^RNAi.UAS.cUa

(Cho et al., 2022)

is ameliorated by nej^{F2161A.UAS.Tag:V5}

(Cho et al., 2022)

is ameliorated by nej^KK113191

(Cho et al., 2022)

is exacerbated by nej^UAS.Tag:V5

(Cho et al., 2022)

is ameliorated by Hsap\PQBP1^UAS.CFP

(Nagai et al., 2003)

Hsap\ATXN3^{tr.Q61.UAS.Tag:HA}

model of Machado-Joseph disease

is exacerbated by Kdm2^EP3093

(Bilen and Bonini, 2007)

model of neurodegenerative disease

is exacerbated by Dcr-1^Q1147X

(Bilen et al., 2006)

is exacerbated by mbl^B2-E1

(Li et al., 2008)

is exacerbated by mbl^UAS.cLa

(Li et al., 2008)

Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}

model of neurodegenerative disease

is exacerbated by Khc⁹

(Gunawardena et al., 2003)

is ameliorated by Hsc70-4^UAS.cEa

(Gunawardena et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

model of Machado-Joseph disease

is ameliorated by Rac1^UAS.cLa

(Lee et al., 2011)

is ameliorated by Pak^{UAS.Tag:Myr(Src64B)}

(Lee et al., 2011)

is exacerbated by Rac1^V12.UAS

(Lee et al., 2011)

is exacerbated by CG7130^GD2776

(Tsou et al., 2015)

is exacerbated by Atg12^JF02704

(Tsou et al., 2015)

is ameliorated by Hsap\ATXN3^{HNHH.UAS.Tag:polyHis}

(Tsou et al., 2015)

is exacerbated by Atg7^GD11671

(Tsou et al., 2015)

is exacerbated by Atg8a^HMS01328

(Tsou et al., 2015)

is exacerbated by CG5001^KK108978

(Tsou et al., 2015)

is exacerbated by CG7220^KK109208

(Tsou et al., 2015)

is ameliorated by Ube4B^JF02691

(Tsou et al., 2015)

is exacerbated by DnaJ-1^HMS00688

(Tsou et al., 2015)

is ameliorated by DnaJ-1^UAS.cKa

(Tsou et al., 2015)

is ameliorated by Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6}

(Tsou et al., 2015)

is ameliorated by eff^HM05268

(Tsou et al., 2015)

is ameliorated by Hsap\ATXN3^{W87A.UAS.Tag:polyHis}

(Tsou et al., 2015)

is ameliorated by Hsc70-3^HMS00397

(Tsou et al., 2015)

is ameliorated by Hsc70-4^JF03136

(Johnson et al., 2020, Tsou et al., 2015)

is ameliorated by park^HMS01651

(Tsou et al., 2015)

is exacerbated by ref(2)P^KK105338

(Tsou et al., 2015)

is exacerbated by sip3^GD3145

(Tsou et al., 2015)

is exacerbated by STUB1^HMS00986

(Tsou et al., 2015)

is ameliorated by Hsap\ATXN3^{UAS.Tag:polyHis}

(Tsou et al., 2015)

is exacerbated by Hsc70-4^K71S.UAS

(Warrick et al., 1999)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Vinatier et al., 2015, Cushman-Nick et al., 2013, Warrick et al., 1999)

is exacerbated by Debcl^RNAi.UAS

(Senoo-Matsuda et al., 2005)

is exacerbated by Buffy^UAS.cQa

(Senoo-Matsuda et al., 2005)

is ameliorated by Debcl^UAS.Tag:HA

(Senoo-Matsuda et al., 2005)

is ameliorated by CG8209^B3-Sa

(Bilen and Bonini, 2007)

is ameliorated by emb^E2-1A

(Bilen and Bonini, 2007)

is ameliorated by dbr^EP9

(Bilen and Bonini, 2007)

is ameliorated by dbr^EP456

(Bilen and Bonini, 2007)

is ameliorated by wech^JM120

(Bilen and Bonini, 2007)

is ameliorated by NFAT^EP1335

(Bilen and Bonini, 2007)

is ameliorated by Imp^EP1433

(Bilen and Bonini, 2007)

is ameliorated by DnaJ-1^EP411

(Bilen and Bonini, 2007)

is ameliorated by Usp47^E213-1A

(Bilen and Bonini, 2007)

is ameliorated by orb2^B8-S

(Bilen and Bonini, 2007)

is ameliorated by CG14207^EP1348

(Bilen and Bonini, 2007)

is ameliorated by wech^EP2594

(Bilen and Bonini, 2007)

is ameliorated by emb^E128-1A

(Bilen and Bonini, 2007)

is ameliorated by wech^E546

(Bilen and Bonini, 2007)

is ameliorated by Faf2^E659

(Bilen and Bonini, 2007)

is ameliorated by Hsp68^E407

(Bilen and Bonini, 2007)

is ameliorated by DnaJ-1^B345.2

(Bilen and Bonini, 2007)

is ameliorated by CG11700^EP1384

(Bilen and Bonini, 2007)

is ameliorated by Sin3A^B9-E

(Bilen and Bonini, 2007)

is ameliorated by wech^JM265

(Bilen and Bonini, 2007)

is ameliorated by Acox1^B227.2

(Bilen and Bonini, 2007)

is ameliorated by mrj^E1050

(Bilen and Bonini, 2007)

is ameliorated by Tpr2^EB7-1A

(Bilen and Bonini, 2007)

is ameliorated by NFAT^EP1508

(Bilen and Bonini, 2007)

is exacerbated by Cdk5^GD13840

(Liman et al., 2014)

is exacerbated by Prosβ2^RNAi.UAS.cUa

(Saitoh et al., 2015)

is exacerbated by Atg12^RNAi.UAS.cUa

(Saitoh et al., 2015)

is exacerbated by bchs^RNAi.UAS.cUa

(Saitoh et al., 2015)

is exacerbated by Atg6⁰⁰⁰⁹⁶

(Saitoh et al., 2015)

is exacerbated by ref(2)P^RNAi.UAS.cUa

(Saitoh et al., 2015)

is exacerbated by ref(2)P^od2

(Saitoh et al., 2015)

is exacerbated by ref(2)P^od3

(Saitoh et al., 2015)

is ameliorated by emb^EY08770

(Sowa et al., 2018)

is NOT exacerbated by cdm^JF01428

(Sowa et al., 2018)

is exacerbated by Kap-α3^UASp.cMa

(Sowa et al., 2018)

is exacerbated by emb^JF01311

(Sowa et al., 2018)

is ameliorated by cdm^GS17666

(Sowa et al., 2018)

is ameliorated by Kap-α3^JF02686

(Sowa et al., 2018)

is ameliorated by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}

(Vinatier et al., 2015)

is ameliorated by PICK1^KK109273

(McGurk and Bonini, 2012)

is ameliorated by PICK1^JF01199

(McGurk and Bonini, 2012)

is exacerbated by RhoGAP68F^KK102738

(McGurk and Bonini, 2012)

is exacerbated by fh^RNAi.UAS.cAa

(McGurk and Bonini, 2012)

is exacerbated by UQCR-C1^KK108539

(McGurk and Bonini, 2012)

is ameliorated by PICK1^ΔEP-147

(McGurk and Bonini, 2012)

is ameliorated by ppk^JF03250

(McGurk and Bonini, 2012)

is exacerbated by mAcon1^KK100999

(McGurk and Bonini, 2012)

is ameliorated by Nach^JF02566

(McGurk and Bonini, 2012)

is ameliorated by Usp2^GD5229

(Voßfeldt et al., 2012)

is exacerbated by CG6873^GD12062

(Voßfeldt et al., 2012)

is exacerbated by Ciz1^GD12382

(Voßfeldt et al., 2012)

is exacerbated by CG33128^GD5069

(Voßfeldt et al., 2012)

is exacerbated by Rab30^GD14116

(Voßfeldt et al., 2012)

is exacerbated by RpS10a^GD7556

(Voßfeldt et al., 2012)

is exacerbated by HisRS^GD1599

(Voßfeldt et al., 2012)

is exacerbated by Sf3b5^GD12979

(Voßfeldt et al., 2012)

is exacerbated by MED14^GD4081

(Voßfeldt et al., 2012)

is exacerbated by Prp8^GD6578

(Voßfeldt et al., 2012)

is exacerbated by Prosβ2^GD10938

(Voßfeldt et al., 2012)

is exacerbated by Nelf-E^GD9903

(Voßfeldt et al., 2012)

is exacerbated by Rpn9^GD6909

(Voßfeldt et al., 2012)

is exacerbated by vnc^GD7454

(Voßfeldt et al., 2012)

is exacerbated by bic^GD5037

(Voßfeldt et al., 2012)

is exacerbated by Uck^GD229

(Voßfeldt et al., 2012)

is exacerbated by Nrx-IV^GD2436

(Voßfeldt et al., 2012)

is exacerbated by CycJ^GD6936

(Voßfeldt et al., 2012)

is ameliorated by EloA^GD1290

(Voßfeldt et al., 2012)

is exacerbated by CG8086^GD12374

(Voßfeldt et al., 2012)

is exacerbated by brun^GD5423

(Voßfeldt et al., 2012)

is ameliorated by ppk14^GD947

(Voßfeldt et al., 2012)

is ameliorated by bwa^GD3476

(Voßfeldt et al., 2012)

is ameliorated by CG17048^GD3783

(Voßfeldt et al., 2012)

is ameliorated by Hsc70-4^GD16584

(Voßfeldt et al., 2012)

is ameliorated by Mal-A1^GD5459

(Voßfeldt et al., 2012)

is ameliorated by Polr2I^GD4234

(Voßfeldt et al., 2012)

is ameliorated by aux^GD7187

(Voßfeldt et al., 2012)

is ameliorated by Gβ13F^GD7011

(Voßfeldt et al., 2012)

is ameliorated by trbd^GD14218

(Voßfeldt et al., 2012)

is ameliorated by CG5687^GD2255

(Voßfeldt et al., 2012)

is ameliorated by 5PtaseI^GD8685

(Voßfeldt et al., 2012)

is ameliorated by Trmt2a^GD11081

(Voßfeldt et al., 2012)

is ameliorated by Hsc70-4^GD11264

(Voßfeldt et al., 2012)

is ameliorated by Herc4^GD2240

(Voßfeldt et al., 2012)

is ameliorated by THADA^GD9074

(Voßfeldt et al., 2012)

is ameliorated by CG17919^GD17025

(Voßfeldt et al., 2012)

is ameliorated by CG16890^GD9226

(Voßfeldt et al., 2012)

is ameliorated by MRG15^GD11902

(Voßfeldt et al., 2012)

is ameliorated by Droj2^GD14050

(Voßfeldt et al., 2012)

is ameliorated by Prim1^GD4566

(Voßfeldt et al., 2012)

is ameliorated by Hsc70-1^GD13532

(Voßfeldt et al., 2012)

is ameliorated by Cad88C^GD2653

(Voßfeldt et al., 2012)

is ameliorated by Dab^GD4886

(Voßfeldt et al., 2012)

is ameliorated by Hrb27C^GD6964

(Voßfeldt et al., 2012)

is ameliorated by roq^GD9209

(Voßfeldt et al., 2012)

is ameliorated by Doa^GD8588

(Voßfeldt et al., 2012)

is ameliorated by Isha^GD11266

(Voßfeldt et al., 2012)

is ameliorated by LanB1^GD13179

(Voßfeldt et al., 2012)

is ameliorated by Stip1^GD9818

(Voßfeldt et al., 2012)

is exacerbated by timeout^GD12305

(Voßfeldt et al., 2012)

is ameliorated by Fbxo42^GD12027

(Voßfeldt et al., 2012)

is exacerbated by chm^GD1235

(Voßfeldt et al., 2012)

is exacerbated by Ccs^GD9458

(Voßfeldt et al., 2012)

is exacerbated by Pkcδ^GD15429

(Voßfeldt et al., 2012)

is exacerbated by CG43795^GD14309

(Voßfeldt et al., 2012)

is exacerbated by Hsf^GD16368

(Voßfeldt et al., 2012)

is exacerbated by PNKP^GD14266

(Voßfeldt et al., 2012)

is exacerbated by AstA-R2^GD339

(Voßfeldt et al., 2012)

is exacerbated by CG15534^GD3127

(Voßfeldt et al., 2012)

is exacerbated by DAAM^GD8382

(Voßfeldt et al., 2012)

is exacerbated by VGlut2^GD3675

(Voßfeldt et al., 2012)

is exacerbated by l(3)neo38^GD12076

(Voßfeldt et al., 2012)

is exacerbated by CG15399^GD9009

(Voßfeldt et al., 2012)

is exacerbated by Marf^GD11094

(Voßfeldt et al., 2012)

is exacerbated by CG12935^GD3496

(Voßfeldt et al., 2012)

is exacerbated by Ars2^GD12300

(Voßfeldt et al., 2012)

is exacerbated by spg^GD10145

(Voßfeldt et al., 2012)

is exacerbated by CG2887^GD9842

(Voßfeldt et al., 2012)

is ameliorated by Prp19^G3080

(Chen et al., 2021)

is exacerbated by Prp19^GD11681

(Chen et al., 2021)

is ameliorated by CrebA^UAS.cUa

(Chung et al., 2017)

is ameliorated by Rac1^UAS.cUa

(Chung et al., 2017)

is ameliorated by Cth^UAS.cSb

(Snijder et al., 2016)

is ameliorated by Hsap\DNAJB6^UAS.Tag:V5

(Bason et al., 2019)

is ameliorated by PNKP^GS21535

(Chakraborty et al., 2020)

is ameliorated by Diap1^UAS.cUa

(Raj and Sarkar, 2019, Singh et al., 2014)

is ameliorated by InR^UAS.ECFP

(Raj and Sarkar, 2019)

is ameliorated by InR^UAS.Exel

(Tandon and Sarkar, 2021, Raj and Sarkar, 2019)

is exacerbated by InR^RNAi.UAS.cUa

(Raj and Sarkar, 2019)

is exacerbated by nej^ΔBHQ.UAS

(Raj and Sarkar, 2019)

is exacerbated by nej^RNAi.UAS.cKa

(Raj and Sarkar, 2019)

is exacerbated by InR^RNAi.UAS.cUa

(Raj and Sarkar, 2019)

is ameliorated by Atg8a^UASp.mCherry

(Chakravorty et al., 2022)

is exacerbated by Cul1^GD9650

(Chen et al., 2019)

is exacerbated by Cul1^NIG.1877R

(Chen et al., 2019)

is exacerbated by FipoQ^KK108266

(Chen et al., 2019)

is exacerbated by FipoQ^NIG.2010R

(Chen et al., 2019)

is exacerbated by Rubicon^UAS.Tag:HA

(Oba et al., 2021)

is exacerbated by Rubicon^{ΔRUN.UAS.Tag:HA}

(Oba et al., 2021)

is ameliorated by Atx2^{ΔPAM2.UAS.Tag:FLAG}

(Xu et al., 2019)

is ameliorated by Atx2^HMS02726

(Xu et al., 2019)

is ameliorated by Scer\HSP104^WT.UAS

(Cushman-Nick et al., 2013)

is exacerbated by Myc^JF01762

(Singh et al., 2014)

is ameliorated by Myc^UAS.cZa

(Singh et al., 2014)

is ameliorated by CalpA^JF03391

(Park et al., 2020)

is ameliorated by CalpA^KK104532

(Park et al., 2020)

is ameliorated by Mmus\Pja1^UAS.cGa

(Ghosh et al., 2021)

is ameliorated by Rack1^KK109073

(Xie et al., 2021)

is ameliorated by Kcmf1^HMS00511

(Xie et al., 2021)

is ameliorated by Usp47^UAS.cXa

(Xie et al., 2021)

is ameliorated by poe^HMS00739

(Xie et al., 2021)

is ameliorated by rl^UAS.Tag:FLAG

(Xie et al., 2021)

is ameliorated by pros^HMJ02107

(Han et al., 2020)

is ameliorated by tup^HMC03317

(Han et al., 2020)

is ameliorated by Charon^KK105778

(Han et al., 2020)

is ameliorated by Dredd^HMS00063

(Han et al., 2020)

is exacerbated by Rel^{68.UAS.Tag:HA}

(Han et al., 2020)

is ameliorated by Rel^GD1199

(Han et al., 2020)

is ameliorated by casp^UAS.Tag:V5

(Han et al., 2020)

is ameliorated by ftz-f1^HMS00019

(Han et al., 2020)

is ameliorated by Hsap\MYC^UAS.1

(Raj and Sarkar, 2017)

is ameliorated by Hsap\MYC^UAS.2

(Raj and Sarkar, 2017)

is ameliorated by Hsap\MYC^UAS.S

(Raj and Sarkar, 2017)

is ameliorated by Droj2^GL00508

(Na et al., 2023)

is exacerbated by Hsp110^HMS01080

(Na et al., 2023)

is exacerbated by Pdk1^JF02807

(Na et al., 2023)

is exacerbated by zip^HMS01618

(Na et al., 2023)

is ameliorated by Hsap\DNAJB1^{UAS.Tag:SS(Unk)}

(De Mena et al., 2017)

is ameliorated by Hsap\HSPA1L^{UAS.cDMa.Tag:SS(Unk)}

(De Mena et al., 2017)

is ameliorated by Hsap\ALKBH3^UAS.cSa

(Sun et al., 2023)

is ameliorated by Trx2^UAS.cUa

(Umeda-Kameyama et al., 2007)

is ameliorated by dhd^UAS.cUa

(Umeda-Kameyama et al., 2007)

is ameliorated by TrxT^UAS.cUa

(Umeda-Kameyama et al., 2007)

is exacerbated by Tbp^sI10

(Hsu et al., 2014)

is exacerbated by Tbp^UAS.cHa

(Hsu et al., 2014)

is ameliorated by Hsc70-4^HMS00152

(Johnson et al., 2020)

is ameliorated by Hsc70-4^GLV21049

(Johnson et al., 2020)

model of autosomal dominant cerebellar ataxia

is exacerbated by Atx2^UAS.cSa

(Lessing and Bonini, 2008, Ghosh and Feany, 2004)

is ameliorated by pAbp^UAS.cSa

(Lessing and Bonini, 2008)

is ameliorated by Atx2^X1

(Lessing and Bonini, 2008)

is exacerbated by nej^EP1179

(Jung and Bonini, 2007)

is ameliorated by nej^P

(Jung and Bonini, 2007)

is ameliorated by mus201^D1

(Jung and Bonini, 2007)

is exacerbated by CG7231^EP2510

(Ghosh and Feany, 2004)

is exacerbated by Hsc70-4^K71S.UAS

(Ghosh and Feany, 2004)

is ameliorated by BacA\p35^UAS.cUa

(Ghosh and Feany, 2004)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Ghosh and Feany, 2004)

is ameliorated by Diap1^UAS.cLa

(Ghosh and Feany, 2004)

is exacerbated by Atx2^EP3145

(Ghosh and Feany, 2004)

is ameliorated by DnaJ-1^UAS.cKa

(Ghosh and Feany, 2004)

is NOT ameliorated by Hsap\ATXN1L^UAS.Tag:FLAG

(Mizutani et al., 2005)

is ameliorated by Hsap\MLF1^UAS.cMa

(Martin-Lanneree et al., 2006)

is ameliorated by Mlf^UAS.cFa

(Martin-Lanneree et al., 2006)

is ameliorated by Mlf^UAS.cKa

(Martin-Lanneree et al., 2006)

is exacerbated by Tg^GD10774

(Lin et al., 2015)

is exacerbated by Tg^KK101591

(Lin et al., 2015)

model of neurodegenerative disease

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Wong et al., 2008, Huen and Chan, 2005, Bonini, 2002, Chan et al., 2000)

is ameliorated by nej^EP1410

(Huen and Chan, 2005)

is exacerbated by Hsc70-4^K71S.UAS

(Huen and Chan, 2005)

is exacerbated by Hsap\HTT^{N548.Q128.UAS}

(Lee et al., 2004)

is ameliorated by Sec61α^EP2567

(Kanuka et al., 2003)

is ameliorated by Sec61α^k04917

(Kanuka et al., 2003)

is ameliorated by DnaJ-1^UAS.Tag:FLAG

(Bonini, 2002, Chan et al., 2000)

is ameliorated by DnaJ-H^UAS.Tag:FLAG

(Chan et al., 2000)

is exacerbated by DnaJ-1^{G295D.UAS.Tag:FLAG}

(Chan et al., 2000)

is exacerbated by DnaJ-1^{ΔJ.UAS.Tag:FLAG}

(Chan et al., 2000)

is exacerbated by Khc⁹

(Gunawardena et al., 2003)

is ameliorated by Hsc70-4^UAS.cEa

(Gunawardena et al., 2003)

is exacerbated by mir-ban^Δ.as.B.UAS

(Bilen et al., 2006)

is exacerbated by mir-ban^EP3622

(Bilen et al., 2006)

is exacerbated by loqs^f00791

(Bilen et al., 2006)

is ameliorated by mir-ban^B90.1

(Bilen et al., 2006)

is ameliorated by mir-ban^D.UAS.EGFP

(Bilen et al., 2006)

is exacerbated by mir-ban^EP3208

(Bilen et al., 2006)

is ameliorated by lncRNA:Hsrω^RNAi.Sym.UAS

(Mallik and Lakhotia, 2009)

is ameliorated by Hsap\RACK1^UAS.cLa

(Lam et al., 2008)

is ameliorated by BacA\p35^UAS.cHa

(Wong et al., 2008)

is ameliorated by Hsap\ATXN3^{Scer\UAS.T:Zzzz\His6}

(Tsou et al., 2013)

is ameliorated by Hsap\ATXN3^{UAS.Tag:polyHis}

(Tsou et al., 2013)

is exacerbated by Hsap\MBNL1^UAS.cGCa

(Li et al., 2008)

is exacerbated by mbl^UAS.cLa

(Li et al., 2008)

is ameliorated by Hsp60D^RNAi.Sym.UAS

(Arya et al., 2010)

is ameliorated by Rpn11^DANC

(Tonoki et al., 2009)

is ameliorated by Rpn11^GS13423

(Tonoki et al., 2009)

is ameliorated by Rpn11^UAS.cTa

(Tonoki et al., 2009)

is exacerbated by Rpn11^RNAi.UAS

(Tonoki et al., 2009)

is exacerbated by U2af50^RNAi.UAS.cUa

(Tsoi et al., 2011)

is exacerbated by U2af50^XR15

(Tsoi et al., 2011)

Hsap\ATXN3^tr.Q46.UAS

model of autosomal dominant cerebellar ataxia

is ameliorated by nej^P

(Jung and Bonini, 2007)

is exacerbated by nej^EP1179

(Jung and Bonini, 2007)

Hsap\ATXN3^{fl.Q78.UAS.Tag:HA}

model of autosomal dominant cerebellar ataxia

is ameliorated by Hsap\VCP^UAS.cBa

(Boeddrich et al., 2006)

model of Machado-Joseph disease

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Cushman-Nick et al., 2013)

is exacerbated by Scer\HSP104^WT.UAS

(Cushman-Nick et al., 2013)

Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

model of neurodegenerative disease

is ameliorated by Hsap\ATXN3^{Scer\UAS.T:Zzzz\His6}

(Burr et al., 2014)

is ameliorated by Hsap\ATXN3^{UAS.Tag:polyHis}

(Burr et al., 2014)

is exacerbated by loqs^f00791

(Bilen et al., 2006)

model of Machado-Joseph disease

is ameliorated by emb^E128-1A

(Chan et al., 2011)

is exacerbated by emb^NIG.13387R

(Chan et al., 2011)

is exacerbated by Cdk5^GD13840

(Liman et al., 2014)

is ameliorated by Rad23^GD4245

(Blount et al., 2014)

is ameliorated by fy³

(Chen et al., 2018)

is ameliorated by fy^KK100638

(Chen et al., 2018)

is ameliorated by Su(var)2-10^JF01408

(Chang et al., 2024)

is ameliorated by Su(var)2-10^JF03384

(Chang et al., 2024)

is exacerbated by Cul1^GD9650

(Chen et al., 2019)

is exacerbated by FipoQ^NIG.2010R

(Chen et al., 2019)

is ameliorated by DnaJ-1^UAS.cKa

(Yeh et al., 2018)

is ameliorated by Hsap\DNAJC6^UAS.Tag:HA

(Yeh et al., 2018)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Yeh et al., 2018)

is ameliorated by Rac1^V12.UAS

(Vu et al., 2018)

model of autosomal dominant cerebellar ataxia

is ameliorated by Hsap\VCP^UAS.cBa

(Boeddrich et al., 2006)

Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}

ameliorates Huntington's disease

modeled by Hsap\HTT^GMR.Q120

(Warrick et al., 2005)

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82.UAS

(Warrick et al., 2005)

DOES NOT ameliorate tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Warrick et al., 2005)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Vinatier et al., 2015)

modeled by Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}

(Vinatier et al., 2015)

ameliorates spinocerebellar ataxia 7

modeled by Hsap\ATXN7^{102Q.T.UAS.Tag:NLS(SV40-largeT)}

(Vinatier et al., 2015)

Hsap\ATXN3^{fl.Q80.UIMmut.UAS.Tag:MYC}

model of Machado-Joseph disease

is ameliorated by Scer\HSP104^WT.UAS

(Cushman-Nick et al., 2013)

Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}

model of Machado-Joseph disease

is ameliorated by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}

(Vinatier et al., 2015)

Hsap\ATXN3^{CAG89.UAS.Tag:HA,Tag:MYC,Tag:polyHis}

model of neurodegenerative disease

is exacerbated by jp^KK107921

(Calpena et al., 2018)

is ameliorated by jp^UAS

(Calpena et al., 2018)

Hsap\ATXN3^{W87A.UAS.Tag:polyHis}

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Tsou et al., 2015)

Hsap\ATXN3^{HNHH.UAS.Tag:polyHis}

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Tsou et al., 2015)

Hsap\ATXN3^UAS.cBa

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{80Q.UbS1mut.UAS}

(Prifti et al., 2022)

Hsap\ATXN3^{UAS.Tag:polyHis}

exacerbates spinocerebellar ataxia 6

modeled by Hsap\CACNA1A^{UAS.αACT.Q70}

(Tsou et al., 2015)

ameliorates neurodegenerative disease

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Burr et al., 2014)

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Tsou et al., 2013)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Tsou et al., 2015)

Hsap\ATXN3^fl.SCA3.UAS

model of Machado-Joseph disease

is ameliorated by Rad23^GD4245

(Sutton et al., 2017)

is exacerbated by Rad23^{UAS.Tag:polyHis}

(Sutton et al., 2017)

is ameliorated by TER94^GL00448

(Ristic et al., 2018)

is ameliorated by TER94^HMS00656

(Ristic et al., 2018)

is ameliorated by Hsc70-4^GLV21049

(Johnson et al., 2020)

is ameliorated by Hsc70-4^JF03136

(Johnson et al., 2020)

is ameliorated by Hsc70-4^HMS00152

(Johnson et al., 2020)

is exacerbated by CG31643^HMC04377

(Ashraf et al., 2020)

is exacerbated by CG31643^HMJ02237

(Ashraf et al., 2020)

is exacerbated by Kdm3^HMS00775

(Ashraf et al., 2020)

is exacerbated by Mi-2^GL00318

(Ashraf et al., 2020)

is exacerbated by Mi-2^HMC03329

(Ashraf et al., 2020)

is exacerbated by Mi-2^HMS00301

(Ashraf et al., 2020)

is exacerbated by Pdk^GL00009

(Ashraf et al., 2020)

is ameliorated by Pdk^JF03050

(Ashraf et al., 2020)

is exacerbated by Ppa^JF01315

(Ashraf et al., 2020)

is exacerbated by TkR99D^HMC03749

(Ashraf et al., 2020)

is exacerbated by TkR99D^JF02663

(Ashraf et al., 2020)

is ameliorated by stg1^HMS02325

(Ashraf et al., 2020)

is exacerbated by Dop1R1^HM04077

(Ashraf et al., 2020)

is exacerbated by Dop1R1^HMC02344

(Ashraf et al., 2020)

is exacerbated by Dop1R2^HMC02893

(Ashraf et al., 2020)

is exacerbated by Dop1R2^JF02043

(Ashraf et al., 2020)

is ameliorated by Eip63E^HM05111

(Ashraf et al., 2020)

is exacerbated by FER^HMS00249

(Ashraf et al., 2020)

Hsap\ATXN3^{UbS2-mild.fl.SCA3.UAS}

model of Machado-Joseph disease

is exacerbated by DnaJ-1^HMS00688

(Sutton et al., 2017)

is ameliorated by DnaJ-1^UAS.cKa

(Sutton et al., 2017)

Hsap\ATXN3^{C14A.fl.SCA3.UAS}

model of Machado-Joseph disease

is ameliorated by Hsap\ATXN3^{80Q.UIMmut.UAS.Tag:HA}

(Prifti et al., 2022)

Hsap\ATXN3^{Q80.C14A.UIMmut.UAS}

model of Machado-Joseph disease

is ameliorated by Scer\HSP104^WT.UAS

(Cushman-Nick et al., 2013)

Hsap\ATXN3^{Q79.Δexon2.UAS}

model of Machado-Joseph disease

is ameliorated by Scer\HSP104^WT.UAS

(Cushman-Nick et al., 2013)

Hsap\ATXN3^{tr.Q76.UAS.Tag:HA,Tag:MYC}

model of Machado-Joseph disease

is ameliorated by DnaJ-1^UAS.cKa

(Kwon et al., 2018)

is ameliorated by foxo^{G.UAS.Tag:FLAG}

(Kwon et al., 2018)

Hsap\ATXN3^{tr.Q70.cc0.UAS.Tag:HA,Tag:MYC}

model of Machado-Joseph disease

is ameliorated by E2f1^UASp.EGFP

(Kwon et al., 2018)

is ameliorated by nub^UAS.cUa

(Kwon et al., 2018)

is ameliorated by Rel^{68.UAS.Tag:FLAG}

(Kwon et al., 2018)

is ameliorated by cnc^{UAS.ORF.GW.Tag:HA}

(Kwon et al., 2018)

is ameliorated by ct^{UAS.ORF.GW.Tag:HA}

(Kwon et al., 2018)

is ameliorated by dsx^{UAS.ORF.GW.Tag:HA}

(Kwon et al., 2018)

is ameliorated by foxo^{G.UAS.Tag:FLAG}

(Kwon et al., 2018)

is ameliorated by foxo^UAS.cPa

(Kwon et al., 2018)

Hsap\ATXN3^{polyQ78.QUAS.Tag:HA}

model of Machado-Joseph disease

is exacerbated by AttA^GD17307

(Li et al., 2018)

is ameliorated by Rel^E20

(Li et al., 2018)

is ameliorated by Rel^GD1199

(Li et al., 2018)

is ameliorated by Rel^HMS00070

(Li et al., 2018)

is exacerbated by Rel^UAS.EGFP

(Li et al., 2018)

Hsap\ATXN3^{80Q.1.UAS.Tag:HA}

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{80Q.UbS1mut.UAS}

(Prifti et al., 2022)

Hsap\ATXN3^{80Q.UAS.Tag:HA}

model of Machado-Joseph disease

is ameliorated by Hsc70-4^GLV21049

(Johnson et al., 2020)

is ameliorated by Hsc70-4^JF03136

(Johnson et al., 2020)

is ameliorated by Hsc70-4^HMS00152

(Johnson et al., 2020)

Hsap\ATXN3^{80Q.UIMmut.UAS.Tag:HA}

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{C14A.fl.SCA3.UAS}

(Prifti et al., 2022)

Hsap\ATXN3^fl.Q77.UAS

model of Machado-Joseph disease

is ameliorated by Mmmm\VCP^{N.UAS.Tag:MYC}

(Johnson et al., 2021)

Hsap\ATXN3^fl.Q80.UAS

model of Machado-Joseph disease

is ameliorated by Mmmm\VCP^{N.UAS.Tag:MYC}

(Johnson et al., 2021)

Hsap\ATXN3^{80Q.UbS1mut.UAS}

model of Machado-Joseph disease

is ameliorated by DnaJ-1^{UAS.ORF.GW.Tag:HA}

(Prifti et al., 2022)

is ameliorated by DnaJ-1^UAS.cKa

(Prifti et al., 2022)

is ameliorated by Hsap\ATXN3^{80Q.1.UAS.Tag:HA}

(Prifti et al., 2022)

is ameliorated by Hsap\ATXN3^UAS.cBa

(Prifti et al., 2022)

Hsap\ATXN3^{80Q-CAGCAA.UAS.cBa.Tag:HA}

model of Machado-Joseph disease

is ameliorated by DnaJ-1^{UAS.cBa.Tag:FLAG}

(Blount et al., 2023)

Hsap\ATXN3^{K117R.80Q-CAGCAA.UAS.Tag:HA}

model of Machado-Joseph disease

is ameliorated by DnaJ-1^{UAS.cBa.Tag:FLAG}

(Blount et al., 2023)

Hsap\ATXN3^{Knull.80Q-CAGCAA.UAS.Tag:HA}

model of Machado-Joseph disease

is ameliorated by DnaJ-1^{UAS.cBa.Tag:FLAG}

(Blount et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hsap\ATXN3 - DnaJ-1

anti tag coimmunoprecipitation, anti tag western blot

(Blount et al., 2023, Prifti et al., 2022)

Hsap\ATXN3 - Rad23

pull down, western blot

(Sutton et al., 2017)

Hsap\ATXN3 - TER94

pull down, western blot, anti tag coimmunoprecipitation

(Johnson et al., 2021, Ristic et al., 2018)

Hsap\ATXN3 - foxo

anti tag coimmunoprecipitation, anti tag western blot

(Kwon et al., 2018)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0024961

Class of Gene

engineered_foreign_gene

Stocks and Reagents

Stocks (13)

Bloomington

8149

w^*; P{UAS-hATXN3.tr-Q27}N18.3d

8150

w^*; P{UAS-hATXN3.tr-Q78}c211.2

83345

w¹¹¹⁸; P{QUAS-hATXN3.polyQ78}3

39756

w^*; P{UAS-ATXN3.CAA91.HisMycHA}02

40535

w^*; P{UAS-ATXN3.CAG89.HAMycHis}01

40537

w^*; P{UAS-ATXN3.CAG14.HisMycHA}02

83344

w¹¹¹⁸; P{QUAS-hATXN3.polyQ27}5/CyO

33609

w¹¹¹⁸; P{UAS-hATXN3.fl-Q27.myc}46.2

39758

w^*; P{UAS-ATXN3.STOP.CAA94.HAMycHis}01

33610

w¹¹¹⁸; P{UAS-hATXN3.fl-Q84.myc}7.2/MKRS

8141

w^*; P{UAS-hATXN3.tr-Q78}c37.3/TM3, Sb¹

39757

w^*; P{UAS-ATXN3.CAG89.HisMycHA}02/TM3, Sb¹

More stocks available...

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (34)

Reported As

Symbol Synonym

ATX-3

(McGurk and Bonini, 2012, Hart and Warrick, 2007)

ATX3

(Fernius et al., 2017, HGNC Curators and FlyBase Curators, 2013-)

ATXN3

(Chang et al., 2024, Chakravorty et al., 2022, Xu et al., 2019, Chen et al., 2018, Sowa et al., 2018, Vu et al., 2018, Sutton et al., 2017, Snijder et al., 2016, McGurk et al., 2015, HGNC Curators and FlyBase Curators, 2013-, Stochmanski et al., 2012, Therrien and Rouleau, 2012.8.30, Elden et al., 2010)

Ataxin-3

(Sousa et al., 2023, Hegde et al., 2014, Jung et al., 2009)

Ataxin-3(SCA3)

(Ristic et al., 2018)

Atx-3

(Boeddrich et al., 2006)

Atx3

(Hsu et al., 2014)

Atxn3

(Prifti et al., 2022, Yeh et al., 2018, Heidari et al., 2015, Reinhardt et al., 2012)

Hsap\ATXN3

(Bhattacharjee et al., 2019)

Hsap\MJD

(Butler et al., 2012)

JOS

(HGNC Curators and FlyBase Curators, 2013-)

MDJ

(Yi et al., 2013)

(Mugat et al., 2008)

MJD/SCA3

(Tonoki et al., 2011)

MJD1

(Lee et al., 2011)

MJDtr

(Chang et al., 2011, Arya et al., 2010, Popiel et al., 2007, Senoo-Matsuda et al., 2005, Nagai et al., 2003)

SCA-3

(Rana et al., 2010, Perutz, 1999)

SCA3tr

(Wu et al., 2023, Singh et al., 2014)

ataxin

(Wu et al., 2024)

ataxin-3

(Barwell and Seroude, 2023, Himalian et al., 2022, Kim et al., 2020, Johnson et al., 2019, Sowa et al., 2018, Matsumoto et al., 2004, Sisodia, 1998)

ataxin3

(Nan et al., 2024)

atx3

(Vinatier et al., 2015)

atxn3

(Tsou et al., 2015)

hATXN3

(Deliu et al., 2022)

Name Synonyms

Ataxin 3

(Nagraj et al., 2007)

Ataxin-3

(Johnson et al., 2020, Lin et al., 2015, McGurk and Bonini, 2012, Arya et al., 2010, Hart and Warrick, 2007)

Ataxin3

(Denton et al., 2020)

Machado-Joseph disease

Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3)

(HGNC Curators and FlyBase Curators, 2013-)

ataxin 3

(Merlo et al., 2014, HGNC Curators and FlyBase Curators, 2013-, Elden et al., 2010)

ataxin-3

(Blount et al., 2018, Wu et al., 2018, Sutton et al., 2017, Lin et al., 2015, Tsou et al., 2015, Tsou et al., 2015, Blount et al., 2014, Boeddrich et al., 2006, Riley, 2006, Perez et al., 1998)

ataxin3

(Lee et al., 2011)

spinocere- bellar ataxia type-3 disease protein

(Perez et al., 1998)

spinocerebellar ataxia 3

(Watson et al., 2008)

spinocerebellar ataxia type 3

(Lee et al., 2011, Bilen et al., 2006)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 8 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

4287

Other crossreferences

Ensembl_Homo_sapiens -

ENSG00000066427

HUGO Gene Nomenclature Committee -

ATXN3; ataxin 3

MARRVEL - MARRVEL (human gene)

ATXN3

OMIM_GENE - Online Mendelian Inheritance in Man (Genes)

ATAXIN 3; ATXN3

OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0024961

References (198)

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