FlyBase Allele Report: Dmel\LanB1[GD13179]

General Information

Symbol

Dmel\LanB1^GD13179

Species

D. melanogaster

Name

FlyBase ID

FBal0207477

Feature type

allele

Associated gene

Dmel\LanB1

Associated Insertion(s)

Carried in Construct

P{GD13179}

Also Known As

UAS-LanB1 RNAi, UAS-LanB1.RNAi^VDRC.v23121, LanB1ⁱ, LanB1-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD13179}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD13179

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Voßfeldt et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | P-stage, with Scer\GAL4^GMR.PF

(Walther et al., 2024)

bang sensitive, with Scer\GAL4^elav.PU

(Yasuda et al., 2025)

decreased rate of adult locomotory behavior, with Scer\GAL4^elav.PU

(Yasuda et al., 2025)

decreased rate of adult locomotory behavior, with Scer\GAL4^insc.PU

(Yasuda et al., 2025)

decreased rate of adult locomotory behavior, with Scer\GAL4^moody.SPG

(Yasuda et al., 2025)

lethal, with Scer\GAL4^da.PU

(Yasuda et al., 2025)

lethal, with Scer\GAL4^{LanB1-CR70822-KO-kG4}

(Yasuda et al., 2025)

lethal, with Scer\GAL4^Tub.PU

(Yasuda et al., 2025)

partially lethal - majority die, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

short lived, with Scer\GAL4^moody.SPG

(Yasuda et al., 2025)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible | adult stage, with Scer\GAL4^bs.Term

(Song et al., 2025)

visible | adult stage, with Scer\GAL4^nub.PU

(Yasuda et al., 2025)

visible | adult stage, with Scer\GAL4^rn-GAL4-5

(Song et al., 2025)

Phenotype Manifest In

basal part of cell | P-stage, with Scer\GAL4^GMR.PF

(Walther et al., 2024)

egg chamber, with Scer\GAL4^tj.PU

(Díaz de la Loza et al., 2017)

haltere | adult stage, with Scer\GAL4^bs.Term

(Song et al., 2025)

haltere | adult stage, with Scer\GAL4^rn-GAL4-5

(Song et al., 2025)

haltere | P-stage, with Scer\GAL4^rn-GAL4-5

(Song et al., 2025)

oocyte, with Scer\GAL4^tj.PU

(Díaz de la Loza et al., 2017)

retina | P-stage, with Scer\GAL4^GMR.PF

(Walther et al., 2024)

wing, with Scer\GAL4^bs.Term

(Song et al., 2025)

wing, with Scer\GAL4^nub.PU

(Yasuda et al., 2025)

wing, with Scer\GAL4^rn-GAL4-5

(Song et al., 2025)

Detailed Description

Statement

Reference

Adults expressing LanB1^GD13179 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in semi-lethality or early pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 10-20% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development