FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TbpUAS.cHa
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General Information
Symbol
Dmel\TbpUAS.cHa
Species
D. melanogaster
Name
FlyBase ID
FBal0302759
Feature type
allele
Associated gene
Dmel\Tbp
Associated Insertion(s)
Carried in Construct
P{UAS-Tbp.H}
Key Links
Transgenic product class
cDNA
(Hsu et al., 2014)
wild_type
(Hsu et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Hsu et al., 2014)
wild_type
(Hsu et al., 2014)
Mutagen
in vitro construct
(Hsu et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Tbp.H}
Cytology
Description

UAS regulatory sequences drive expression of a Tbp cDNA clone (LD44083).

(Hsu et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Tbp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The rhabdomeres appear normal and well-organised in flies expressing TbpScer\UAS.cHa under the control of Scer\GAL4GMR.PU. There is no obvious damage to the internal ommatidial structure.

      (Hsu et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of TbpScer\UAS.cHa and Hsap\TBP36Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU has no effect on eye morphology.

      Expression of TbpScer\UAS.cHa does not suppress the depigmentation phenotype seen in the eyes of flies expressing Hsap\TBP36Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU.

      Expression of TbpScer\UAS.cHa enhances the photoreceptor loss seen in 7-week old flies when Hsap\TBP109Q.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU. Rhabdomere fusion is seen, and additional and large inclusions are observed.

      Expression of TbpScer\UAS.cHa enhances the rough eye phenotype seen in the eyes of flies expressing Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU. The number of photoreceptors is also further reduced and there is an increase in aggregate formation.

      Co-expressing TbpScer\UAS.cHa and Hsap\HTT97QP.Scer\UAS under the control of Scer\GAL4GMR.PU induces severe retinal degeneration. The photoreceptor loss seen in Hsap\HTT97QP.Scer\UAS-expressing flies is enhanced, and there is increased protein aggregate formation.

      (Hsu et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TbpScer\UAS.cHa
      TbpUAS.cHa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)