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General Information
Symbol
Dmel\Rel68.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0246191
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Rel68, UAS-Flag-Rel.68, UAS-Rel.68
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS drives expression of a 68 kDa N-terminal fragment of Rel, which represents the 'active' cleavage product of full-length Rel, tagged with Tag:FLAG.

UASt regulatory sequences drive expression of amino acid residues 1-545 of Rel (the "REL-68" product) which is tagged at the N-terminal end with Tag:FLAG.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing Rel68.UAS.Tag:FLAG under the control of Scer\GAL4GMR.PU have eyes with reduced eye curvature, glassy appearance with visibly reduced ommatidial facets and nonuniform and diminished pigmentation as compared to WT. Flies expressing two copies of Rel68.UAS.Tag:FLAG under the control of Scer\GAL4GMR.PU causes complete ablation of eye.

Flies expressing Rel68.UAS.Tag:FLAG in the wing pouch under the control of Scer\GAL4Bx-MS1096 have stark wing phenotype (significant size reduction, no longitudinal and transverse veins and wings with downward curvature) as compared to WT control.

Flies overexpressing Rel68.UAS.Tag:FLAG under the control of Scer\GAL4GMR.long show retinal degeneration from 1 week after the onset of expression with progressive deterioration with time.

Flies expressing Rel68.UAS.Tag:FLAG in neurons under the control of Scer\GAL4elav.PU show significantly high female lethality. The fewer surviving eclosing females have a defective unfurling wing, but show normal locomotor behavior.

Larvae expressing Rel68.Scer\UAS.T:Zzzz\FLAG under the control of either Scer\GAL4fat or Scer\GAL4C7 have increased levels of triacylglycerols compared to wild type.

Scer\GAL4da.G32, Rel68.Scer\UAS.T:Zzzz\FLAG flies develop normally but many are unable to eclose.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of mtdScer\UAS.RH rescues the eclosion defect of Scer\GAL4da.G32, Rel68.Scer\UAS.T:Zzzz\FLAG flies.

Co-expression of mtdScer\UAS.RC exacerbates the eclosion defect of Scer\GAL4da.G32, Rel68.Scer\UAS.T:Zzzz\FLAG flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Rel68.Scer\UAS.T:Zzzz\FLAG
Rel68.UAS.Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (11)