FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC
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General Information
Symbol
Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0345022
Feature type
allele
Associated gene
Hsap\ATXN3
Associated Insertion(s)
Carried in Construct
PBac{UAS-hATXN3.tr.Q70.cc0}
Key Links
Transgenic product class
inframe_deletion
(Kwon et al., 2018)
missense_variant
(Kwon et al., 2018)
trinucleotide_repeat_expansion
(Kwon et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Kwon et al., 2018)
missense_variant
(Kwon et al., 2018)
trinucleotide_repeat_expansion
(Kwon et al., 2018)
Mutagen
in vitro construct
(Kwon et al., 2018)
Progenitor genotype
Carried in construct
PBac{UAS-hATXN3.tr.Q70.cc0}
Cytology
Description

UAS regulatory sequences drive expression of a truncated form of Hsap\ATXN3, consisting of a Q repeat region of 70 residues flanked upstream by 14 amino acids and downstream by 43 amino acids. The Q repeat region contains only α-helical coiled-coil structures, and lacks β-sheet motifs due to the insertion of Q to N and Q to E β-sheet-breaking mutations. The protein is tagged at the N-terminal end with Tag:HA and at the C-terminal end with Tag:MYC.

(Kwon et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\ATXN3
Tagged with
Tag:HA
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Machado-Joseph disease
      CEA
      (Kwon et al., 2018)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Machado-Joseph disease
      is ameliorated by E2f1UASp.EGFP
      (Kwon et al., 2018)
      is ameliorated by nubUAS.cUa
      (Kwon et al., 2018)
      is ameliorated by Rel68.UAS.Tag:FLAG
      (Kwon et al., 2018)
      is ameliorated by cncUAS.ORF.GW.Tag:HA
      (Kwon et al., 2018)
      is ameliorated by ctUAS.ORF.GW.Tag:HA
      (Kwon et al., 2018)
      is ameliorated by dsxUAS.ORF.GW.Tag:HA
      (Kwon et al., 2018)
      is ameliorated by foxoG.UAS.Tag:FLAG
      (Kwon et al., 2018)
      is ameliorated by foxoUAS.cPa
      (Kwon et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Kwon et al., 2018)
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC under the control of Scer\GAL4ppk.PU results in severe reductions in the number of terminal dendrites and dendrite branch points of class IV dendritic arborizing neurons in third instar larvae compared to wild-type controls, while Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC proteins accumulate in the nucleus.

      Expressing Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC under the control of Scer\GAL4109(2)80 results in a severely disrupted actin cytoskeleton in distal dendrites of dendritic arborizing neurons in third instar larvae. Third instar larvae are significantly less motile and show more frequent head turning than wild-type controls.

      Expressing Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC under the control of Scer\GAL4221 has no effect on dendrite morphology in class I dendritic arborizing neurons.

      (Kwon et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by nubUAS.cUa, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by E2f1UASp.EGFP, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by Rel68.UAS.Tag:FLAG, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by MedUAS.ORF.GW.Tag:HA, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by cncUAS.ORF.GW.Tag:HA, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by foxoG.UAS.Tag:FLAG, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4109(2)80 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible | partially by foxoUAS.cPa, Scer\GAL4109(2)80

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by DnaJ-1UAS.cKa, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by foxoUAS.cPa, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by ctUAS.ORF.GW.Tag:HA, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by kayUAS.Tag:FLAG, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by dsxUAS.ORF.GW.Tag:HA, Scer\GAL4ppk.PU

      (Kwon et al., 2018)
      NOT suppressed by
      Suppressor of
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by foxoUAS.cPa, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by ctUAS.ORF.GW.Tag:HA, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by kayUAS.Tag:FLAG, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by dsxUAS.ORF.GW.Tag:HA, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by nubUAS.cUa, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by E2f1UASp.EGFP, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by Rel68.UAS.Tag:FLAG, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by MedUAS.ORF.GW.Tag:HA, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by cncUAS.ORF.GW.Tag:HA, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by foxoG.UAS.Tag:FLAG, Scer\GAL4ppk.PU

      (Kwon et al., 2018)

      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC, Scer\GAL4ppk.PU has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by DnaJ-1UAS.cKa, Scer\GAL4ppk.PU

      (Kwon et al., 2018)
      NOT suppressed by
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\ATXN3tr.Q70.cc0.UAS.Tag:HA,Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)