FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\ClC-b1
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General Information
Symbol
Dmel\ClC-b1
Species
D. melanogaster
Name
FlyBase ID
FBal0341718
Feature type
allele
Associated gene
Dmel\ClC-b
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Wong et al., 2017)
Progenitor genotype
P{EP}ClC-bG2453
(Wong et al., 2017)
Cytology
Description

Imprecise excision of P{EP}ClC-bG2453 results in a deletion of the region corresponding to +519 to +2389 base pairs relative to the ClC-b translation start site.

(Wong et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:12,572,657..12,574,527 [+]
Comment:

A 1871bp deletion resulting from the imprecise excision of P{EP}ClC-bG2453. The deletion is reported to extend from +519 to +2389 relative to the ClC-b translation start site and was mapped by the curator relative to the A of the ATG.

(Wong et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ClC-b1 homozygous individuals injected with the non-pathogenic bacteria, E. coli, are unable to clear the bacteria but do not exhibit a significant decrease in survival, as compared to equally infected controls; ClC-b1/ClC-b2 and ClC-b1/Df(2R)Exel7121 individuals are also unable to clear bacteria after injection.

      ClC-b1 homozygous individuals show no alterations in melanization upon wounding or bacterial infection and no changes in the number or size of circulating larval hemocytes, as compared to controls. Isolated circulating naive macrophages from ClC-b1 mutant larvae and adults show delayed clearing of E.coli but normal abilities to engulf/internalize bacteria/bacterial particles upon single infections, as compared to equally infected controls; upon repeated infection, the larval macrophages show decreased uptake of bacteria compared to equally infected controls.

      (Wong et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ClC-b1 is rescued by ClC-b+tCH322-146D02

      (Wong et al., 2017)

      ClC-b1 is rescued by ClC-bUAS.cWa/Scer\GAL4He.PZ

      (Wong et al., 2017)
      Partially rescued by

      ClC-b1 is partially rescued by Scer\GAL4He.PZ/ClC-bunc.UAS.Tag:MYC

      (Wong et al., 2017)
      Not rescued by

      ClC-b1 is not rescued by ClC-btd.UAS.Tag:MYC/Scer\GAL4He.PZ

      (Wong et al., 2017)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ClC-b1
      (Wong et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)