FB2021_02, released April 13, 2021

Allele: Dmel\RelHM05154

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General Information
Symbol
Dmel\RelHM05154
Species
D. melanogaster
Name
FlyBase ID
FBal0240283
Feature type
allele
Associated gene
Dmel\Rel
Associated Insertion(s)
Carried in Construct
P{TRiP.HM05154}
Also Known As
UAS-relish-RNAi
Key Links
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Perkins et al., 2009)
in vitro construct - regulatory fusion
(Perkins et al., 2009)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{TRiP.HM05154}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of an inverted repeat.

      (Perkins et al., 2009)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      Rel
      Also carries
      loxP
      Associated Sequence Features
      dsRNA-HM05154
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Individuals expressing RelHM05154 under the control of Scer\GAL4He.PZ or Scer\GAL4Hml.Δ present a significantly increased bacterial load upon infection with the non-pathogenic E. coli, as compared to equally infected controls.

      (Wong et al., 2017)

      Expression of RelHM05154 in C-IV neurons under the control of Scer\GAL4ppk.1.9 results in a reduction in total dendritic length in ddaC and v'ada neurons.

      (Iyer et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      RelHM05154, Scer\GAL4Hml.Δ has abnormal immune response | adult stage phenotype, non-suppressible by ClC-b1/ClC-b1

      (Wong et al., 2017)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4He.PZ/RelHM05154 is a non-suppressor of abnormal immune response | recessive | adult stage phenotype of ClC-b1

      (Wong et al., 2017)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of vtdGL00522 under the control of Scer\GAL4en.PU (together with Dicer-2, for efficient RNAi) results in increased numbers of hemocytes on the surface of third instar larval wing discs, as compared to controls, which are suppressed by co-expressing RelHM05154.

      (Liu et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      RelHM05154
      Name Synonyms
      Secondary FlyBase IDs
        References (9)