FlyBase Allele Report: Dmel\FipoQ[NIG.2010R]

General Information

Symbol

Dmel\FipoQ^NIG.2010R

Species

D. melanogaster

Name

FlyBase ID

FBal0273006

Feature type

allele

Associated gene

Dmel\FipoQ

Associated Insertion(s)

Carried in Construct

P{NIG.2010R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.2010R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-2010R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Chen et al., 2019)

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Chen et al., 2019)

exacerbates neurodegenerative disease

modeled by Hsap\AR^{Q112.UAS.Tag:HA}

(Chen et al., 2019)

modeled by Zzzz\CAG^{Q76.UAS.EGFP,Tag:FLAG}

(Chen et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing FipoQ^NIG.2010R under the control of Scer\GAL4^GMR.PU do not present any obvious eye defects.

(Chen et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

FipoQ^NIG.2010R, Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-enhanceable by Cul1^GD9650, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Enhancer of

Statement

Reference

FipoQ^NIG.2010R, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage | progressive phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

FipoQ^NIG.2010R, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\AR^{Q112.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

FipoQ^NIG.2010R, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^{Q76.UAS.EGFP,Tag:FLAG}

(Chen et al., 2019)

NOT Enhancer of

Statement

Reference

Scer\GAL4^GMR.PU, FipoQ^NIG.2010R is a non-enhancer of visible | adult stage phenotype of Cul1^GD9650, Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Other

Statement

Reference

FipoQ^NIG.2010R, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has increased cell death | adult stage phenotype

(Chen et al., 2019)

FipoQ^NIG.2010R, Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype

(Chen et al., 2019)

FipoQ^NIG.2010R, Scer\GAL4^GMR.PU, Zzzz\CAG^{Q76.UAS.EGFP,Tag:FLAG} has increased cell death | adult stage phenotype

(Chen et al., 2019)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

FipoQ^NIG.2010R, Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Cul1^GD9650, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Enhancer of

Statement

Reference

FipoQ^NIG.2010R, Scer\GAL4^GMR.PU is an enhancer of eye | progressive phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

FipoQ^NIG.2010R, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\AR^{Q112.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

FipoQ^NIG.2010R, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^{Q76.UAS.EGFP,Tag:FLAG}

(Chen et al., 2019)

NOT Enhancer of

Statement

Reference

Scer\GAL4^GMR.PU, FipoQ^NIG.2010R is a non-enhancer of eye phenotype of Cul1^GD9650, Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Other

Statement

Reference

FipoQ^NIG.2010R, Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype

(Chen et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The eye defects induced by the expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PU are aggravated by the co-expression of FipoQ^NIG.2010R to the point of even leading to necrotic scars.

Adults co-expressing Hsap\ATXN3^{tr.Q27.UAS.Tag:HA} and FipoQ^NIG.2010R under the control of Scer\GAL4^GMR.PU do not present any obvious eye defects.

Adults co-expressing Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC} and FipoQ^NIG.2010R under the control of Scer\GAL4^GMR.PU display mild eye depigmentation; this phenotype is not enhanced by the additional expression of Cul1^GD9650.

(Chen et al., 2019)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

NIG-Fly

2010R-1

P{NIG.2010R}1

2010R-2

P{NIG.2010R}2