FB2020_06, released Dec 22, 2020

Allele: Dmel\Hsc70-4GD11264

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General Information
Symbol
Dmel\Hsc70-4GD11264
Species
D. melanogaster
Name
FlyBase ID
FBal0207332
Feature type
allele
Associated gene
Dmel\Hsc70-4
Associated Insertion(s)
Carried in Construct
P{GD11264}
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Dickson et al., 2007.7.18)
in vitro construct - regulatory fusion
(Dickson et al., 2007.7.18)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{GD11264}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UASt regulatory sequences drive expression of an inverted repeat.

      (Dickson et al., 2007.7.18)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UASt
      Encoded product / tool
      Hsc70-4
      Associated Sequence Features
      dsRNA-GD11264
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Voßfeldt et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing Hsc70-4GD11264 under the control of the cardioblast-specific Scer\GAL4tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

      (Neely et al., 2010)

      Expression under the control of Scer\GAL4Mef2.PR results in grossly normal adult indirect flight muscles.

      Expression under the control of Scer\GAL4Mef2.PR results in frayed myofibrils in the adult indirect flight muscles.

      Expression under the control of Scer\GAL4Mef2.PR results in sarcomeres with broadened Z-lines in the adult indirect flight muscles.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 80-90% of the Scer\GAL4pnr-MD237-expressing area of the notum.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsc70-4GD11264
      Name Synonyms
      Secondary FlyBase IDs
        References (5)