FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sec61αk04917
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General Information
Symbol
Dmel\Sec61αk04917
Species
D. melanogaster
Name
FlyBase ID
FBal0057094
Feature type
allele
Associated gene
Dmel\Sec61α
Associated Insertion(s)
P{lacW}Sec61αk04917
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Wang and Ward, 2010)
Mutagen
P-element activity
(Beaton, 1997.3.4)
Progenitor genotype
Associated Insertion(s)
P{lacW}Sec61αk04917
Cytology
Description

Insertion in the second intron.

(Wang and Ward, 2010)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Kanuka et al., 2003)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Transheterozygous combination of Sec61αk04917/Sec61αEP2567 suppresses neurodegenerative disease induced by Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1.

      (Kanuka et al., 2003)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      autophagic vacuole & larval fat body | somatic clone | cell autonomous

      (Arsham and Neufeld, 2009)

      lysosome & larval fat body | somatic clone | cell autonomous

      (Arsham and Neufeld, 2009)
      Detailed Description
      Statement
      Reference

      Sec61α1/Sec61αk04917 animals show 46 +/- 6% embryonic lethality, with the majority of the animals dying during the early first larval instar.

      Homozygous animals show 58 +/- 8% embryonic lethality, with the remainder of the animals dying during the early first larval instar.

      (Wang and Ward, 2010)

      Sec61αk04917 clones in fat bodies from well-fed early third instar larvae accumulate lysosomes, as indicated by elevated LysoTracker staining, and show redistribution of the Atg8a product into autophagosomes.

      (Arsham and Neufeld, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Sec61αk04917/Sec61alpha[+] is a suppressor of visible | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Sec61αk04917/Sec61alpha[+] is a suppressor of eye | heat sensitive phenotype of peb1

      (Wilk et al., 2004)

      Sec61αk04917 is a suppressor of eye phenotype of Hsap\ATXN3tr.Q78.UAS.Tag:HA, Scer\GAL4GMR.PF

      (Kanuka et al., 2003)

      Sec61αk04917 is a suppressor of ommatidium phenotype of Hsap\ATXN3tr.Q78.UAS.Tag:HA, Scer\GAL4GMR.PF

      (Kanuka et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Sec61αk04917 is partially rescued by Sec61αt4.4

      (Wang and Ward, 2010)
      Comments

      Sec61αt4.4 rescues the lethality of Sec61αk04917 so that more than 70% of the rescued animals are viable as adults.

      (Wang and Ward, 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Lethality is revertable on excision of the P{lacW}.

      (Kanuka et al., 2003)

      Fails to complement: l(2)00455b00455b.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      P560
      (Kanuka et al., 2003)
      Sec61k04917
      (Wilk et al., 2004)
      Sec61αP560
      (Kanuka et al., 2003)
      Sec61αk04917
      (Wang and Ward, 2010, Arsham and Neufeld, 2009)
      l(2)k04917
      (Spradling et al., 1999)
      l(2)k04917k04917
      (Beaton, 1997.3.4, BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)