FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sec61αt4.4
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General Information
Symbol
Dmel\Sec61αt4.4
Species
D. melanogaster
Name
FlyBase ID
FBal0246698
Feature type
allele
Associated gene
Dmel\Sec61α
Associated Insertion(s)
Carried in Construct
P{Sec61α.4.4}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Wang and Ward, 2010)
wild_type
(Wang and Ward, 2010)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Wang and Ward, 2010)
wild_type
(Wang and Ward, 2010)
Mutagen
in vitro construct
(Wang and Ward, 2010)
Progenitor genotype
Carried in construct
P{Sec61α.4.4}
Cytology
Description

4.4kb genomic fragment containing the entire Sec61α gene and extending approximately 100bp into the upstream gene DLP and approximately 350bp into the downstream gene CG9536.

(Wang and Ward, 2010)
Allele components
Component
Use(s)
Regulatory region(s)
Sec61α
Encoded product / tool
Sec61α
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
2L:6,476,629..6,481,044 [-]
Comment:

4.4kb genomic fragment containing the entire Sec61α gene and extending approximately 100bp into the upstream gene DLP and approximately 350bp into the downstream gene CG9536. Endpoints based on primer sequences.

(Wang and Ward, 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Sec61αt4.4 partially rescues Sec61αk04917

      (Wang and Ward, 2010)

      Sec61αt4.4 partially rescues Sec61α1

      (Wang and Ward, 2010)
      Comments

      Sec61αt4.4 rescues the cuticle defects and embryonic lethality of Sec61α1 embryos, but most of the rescued animals die as pharate adults.

      Sec61αt4.4 rescues the lethality of Sec61αk04917 so that more than 70% of the rescued animals are viable as adults.

      (Wang and Ward, 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Sec61αt4.4
      Name Synonyms
      Secondary FlyBase IDs
        References (1)