FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TgGD10774
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General Information
Symbol
Dmel\TgGD10774
Species
D. melanogaster
Name
FlyBase ID
FBal0205434
Feature type
allele
Associated gene
Dmel\Tg
Associated Insertion(s)
Carried in Construct
P{GD10774}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD10774}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD10774
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  autosomal dominant cerebellar ataxia
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Lin et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing TgGD10774 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      Expression of TgGD10774 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) results in viable flies or partial lethality, depending on the particular P{GD10774} insertion line used.

      (Neely et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of TgGD10774 exacerbates the Scer\GAL4GMR.PU>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 eye phenotype. TgGD10774 increases neuron death as well as the area affected by retinal collapse and loss of pigmentation.

      Co-expression of TgGD10774 with Scer\GAL4da.PU>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 exhibit results in a mild reduction if the lifespan of Scer\GAL4da.PU>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 flies.

      Co-expression of TgGD10774 with Scer\GAL4da.PU>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 exacerbates the locomotor activity defects in Scer\GAL4da.PU>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 flies.

      (Lin et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG7356GD10774
      TgGD10774
      Name Synonyms
      Secondary FlyBase IDs
        References (8)