FlyBase Allele Report: Dmel\Trmt2a[GD11081]

General Information

Symbol

Dmel\Trmt2a^GD11081

Species

D. melanogaster

Name

FlyBase ID

FBal0204083

Feature type

allele

Associated gene

Dmel\Trmt2a

Associated Insertion(s)

Carried in Construct

P{GD11081}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11081}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11081

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Voßfeldt et al., 2012)

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Butzlaff et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal sleep | male, with Scer\GAL4^elav-C155

(Maurer et al., 2020)

decreased rate of movement | adult stage, with Scer\GAL4^elav-C155

(Maurer et al., 2020)

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of CG3808^GD11081 under the control of Scer\GAL4^elav-C155 leads to a decrease in walking activity. Males show longer night-time sleep bouts.

(Maurer et al., 2020)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11081

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^GMR.long/Trmt2a^GD11081 is a suppressor of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Other

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF, Trmt2a^GD11081 has lethal phenotype

(Butzlaff et al., 2015)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF/Trmt2a^GD11081 is a non-enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.long/Trmt2a^GD11081 is a suppressor of eye phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Scer\GAL4^GMR.long/Trmt2a^GD11081 is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Trmt2a^GD11081 is a non-suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v34713

w¹¹¹⁸; P{GD11081}v34713

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11081

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG3808^GD11081

Trmt2a^GD11081

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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