FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TbpsI10
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General Information
Symbol
Dmel\TbpsI10
Species
D. melanogaster
Name
FlyBase ID
FBal0058115
Feature type
allele
Associated gene
Dmel\Tbp
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Verheyen et al., 1996)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Hsu et al., 2014)
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous TbpsI10 mutant flies can survive to adulthood without obvious morphological defects, but suffer severe mobility defects. Newly eclosed flies perform significantly less well than wild type flies of the same age in climbing assays. TbpsI10/+ mutant flies have a significantly shorter lifespan than their wild type counterparts.

      No anatomic abnormalities are observed in the nervous systems of newly eclosed TbpsI10/+ mutant flies. The gross morphology of the brain, such as the major projection system and brain volume appear normal. More and larger vacuoles are observed in the cortex and neuropil of older TbpsI10 heterozygous brains compared to wild type controls. External eye morphology appears normal.

      Homozygous TbpsI10 mutant flies do not display any obvious damage in the internal ommatidial structure of the eye.

      (Hsu et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      TbpsI10 is a non-enhancer of visible phenotype of Hsap\TBP36Q.UAS.Tag:HA, Scer\GAL4GMR.PU

      (Hsu et al., 2014)
      Phenotype Manifest In
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      TbpsI10 is a non-enhancer of eye phenotype of Hsap\TBP36Q.UAS.Tag:HA, Scer\GAL4GMR.PU

      (Hsu et al., 2014)
      Suppressor of
      Statement
      Reference

      TbpsI10 is a suppressor of phenotype of Nact.sev

      (Verheyen et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Second site dominant suppressor of Nact.sev that reduces the external roughness of the eye, in addition to causing the overall eye shape to become both rounder and larger, and less refractile.

      (Verheyen et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference

      TbpsI10 does not enhance the rough eye phenotype seen in 7-week old flies when Hsap\TBP36Q.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU.

      TbpsI10 enhances the eye phenotype seen in 7-week old flies when Hsap\TBP109Q.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU. The external ommatidial structures are uneven and large patches of depigmentation appear in the eyes. The number of photoreceptors is significantly reduced and rhabdomere fusion is seen.

      TbpsI10 enhances the photoreceptor loss seen in the eyes of flies expressing Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU. There is a reduction in the number of protein inclusions seen.

      TbpsI10 enhances the eye phenotypes seen when Hsap\HTT97QP.Scer\UAS is expressed under the control of Scer\GAL4GMR.PU. The eyes appear glassy with large necrotic patches and the photoreceptor loss is also further reduced. TbpsI10 has no effect on the amount of protein aggregates seen.

      TbpsI10 enhances the eye phenotypes seen when Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU. The eyes appear glassy with large necrotic patches.

      (Hsu et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TbpSI10
      (Neves and Eisenman, 2019)
      TbpsI10
      (Hsu et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)