FB2026_02 , released June 18, 2026
Allele: Hsap\TBP36Q.UAS.Tag:HA
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General Information
Symbol
Hsap\TBP36Q.UAS.Tag:HA
Species
H. sapiens
Name
FlyBase ID
FBal0302754
Feature type
allele
Associated gene
Hsap\TBP
Associated Insertion(s)
Carried in Construct
P{UAS-Hsap\TBP-HA.36Q}
Key Links
Transgenic product class
wild_type
(Hsu et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hsu et al., 2014)
Mutagen
in vitro construct
(Hsu et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Hsap\TBP-HA.36Q}
Cytology
Description

UAS regulatory sequences drive expression of full length Hsap\TBP with the wild type 36 glutamine residues, tagged at the C-terminal end with Tag:HA.

(Hsu et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\TBP
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\TBP36Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU does not cause age-dependent morphological defects in the eyes of the adult flies when compared with controls. Insoluble inclusions are not observed in the eye discs of the flies.

      Flies expressing Hsap\TBP36Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PU exhibit similar age-dependent loss of motor function to controls at 20 days. Motor function seems lower than controls at 40 days, but this is not statistically significant. Lifespan is significantly reduced compared to controls. Protein aggregates are not detected in the heads of flies between two days and three weeks after eclosion.

      (Hsu et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Hsap\TBP36Q.UAS.Tag:HA, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by TbpsI10

      (Hsu et al., 2014)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Hsap\TBP36Q.UAS.Tag:HA, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by TbpsI10

      (Hsu et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      TbpsI10 does not enhance the rough eye phenotype seen in 7-week old flies when Hsap\TBP36Q.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU.

      Co-expression of TbpScer\UAS.cHa and Hsap\TBP36Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU has no effect on eye morphology.

      Expression of TbpScer\UAS.cHa does not suppress the depigmentation phenotype seen in the eyes of flies expressing Hsap\TBP36Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU.

      (Hsu et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\TBP36Q.Scer\UAS.T:Ivir\HA1
      Hsap\TBP36Q.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)