FlyBase Allele Report: Dmel\Buffy[UAS.cQa]

General Information

Symbol

Dmel\Buffy^UAS.cQa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Quinn

FlyBase ID

FBal0150944

Feature type

allele

Associated gene

Dmel\Buffy

Associated Insertion(s)

Carried in Construct

P{UAS-Buffy.Q}

Also Known As

UAS-buffy

Key Links

Transgenic product class

wild_type

(Quinn et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Quinn et al., 2003)

Mutagen

in vitro construct

(Quinn et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-Buffy.Q}

Cytology

Description

UASt sequences drives expression of Buffy.

(Quinn et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Buffy

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cFa

(M'Angale and Staveley, 2016)

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Fedele et al., 2022)

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Senoo-Matsuda et al., 2005)

ameliorates myopathy with extrapyramidal signs

modeled by MICU1^GD4927

(M'Angale and Staveley, 2017)

ameliorates neurodegenerative disease

modeled by porin^JF03251

(M'Angale and Staveley, 2016)

ameliorates Parkinson's disease

modeled by HtrA2^GD13932

(M'Angale and Staveley, 2017)

modeled by Pdxk^KK108240

(M'Angale and Staveley, 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Adult flies expressing Buffy^UAS.cQa under the control of Scer\GAL4^GMR.PF does not induce any eye morphology defects.

(M'Angale and Staveley, 2017)

Flies with expression of Buffy^Scer\UAS.cQa driven by Scer\GAL4^Ddc.PL have an increase in lifespan and climbing ability compared to controls.

(M'Angale and Staveley, 2016)

Expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^Ddc.PL does not have a significant effect on adult survival or locomotion (climbing ability).

(M'Angale and Staveley, 2016)

The expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^GMR.PU does not lead to any obvious ommatidial defects, as compared to controls.

(M'Angale and Staveley, 2016)

Expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^GMR.PF does not disrupt adult eye morphology compared to controls.

(M'Angale and Staveley, 2016)

Expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^ppk.1.9 in ddaC neurons has no affect on the density of mitochondria (assayed by the expression of markers with a mitochondrial targeting signal).

Expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^ppk.1.9 in ddaC neuron clones has no effect on total length of dendritic branches.

(Tsubouchi et al., 2009)

Overexpression of Buffy^Scer\UAS.cQa, under the control of Scer\GAL4^hs.PB following a heat shock, reduces the ATP levels in adult flies.

Lifespan is reduced when Buffy^Scer\UAS.cQa is expressed under the control of Scer\GAL4^elav-C155 (63.6 days vs. 78.3 days in controls).

(Senoo-Matsuda et al., 2005)

When Buffy^Scer\UAS.cQa is driven by Scer\GAL4^en-e16E, about half the number of cells undergoing cell death are seen when compared to controls. When these embryos are γ irradiated the amount of cell death seen is much reduced compared to wild-type. In these embryos inhibition of rapid embryonic cell cycles, mitotic cells are almost eliminated in those cells expressing Buffy^Scer\UAS.cQa. An accumulation of cells in G1 is seen - cell cycle arrest appear to occur at G1 early S phase. Expression of 2 copies of Buffy^Scer\UAS.cQa by Scer\GAL4^en-e16E is lethal. Scer\GAL4^GMR.PF driven by Scer\GAL4^GMR.PF produces flies with eyes with a wild-type appearance.

(Quinn et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is an enhancer of short lived phenotype of Scer\GAL4^Ddc.PL, park^RNAi.UAS

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is an enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^Ddc.PL, park^RNAi.UAS

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Pi3K59F^KK107602, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Atg6^GD11647, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is an enhancer of short lived phenotype of Atg6^GD11647, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Atg6^GD11647, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^elav-C155 is an enhancer of short lived phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155

(Senoo-Matsuda et al., 2005)

NOT Enhancer of

Statement

Reference

Buffy^UAS.cQa, Scer\GAL4^GMR.PFa is a non-enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Suppressor of

Statement

Reference

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of short lived phenotype of MICU1^GD4927, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of MICU1^GD4927, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^GMR.PF is a suppressor | partially of visible | adult stage phenotype of MICU1^GD4927, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of short lived phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of visible phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Lfg^KK104535, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of abnormal locomotor behavior | adult stage phenotype of Lfg^KK104535, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of visible | adult stage phenotype of Lfg^KK104535, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Lfg^HMS00225, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of abnormal locomotor behavior | adult stage phenotype of Lfg^HMS00225, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of visible | adult stage phenotype of Lfg^HMS00225, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Pi3K59F^KK107602, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Pi3K59F^KK107602, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of short lived phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of abnormal locomotor behavior | progressive phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^arm.PS is a suppressor | partially of flightless | progressive phenotype of Pten¹/Pten⁵

(Mensah et al., 2015)

Buffy^UAS.cQa/Scer\GAL4^how-24B is a suppressor | partially of flightless | progressive phenotype of Pten¹/Pten⁵

(Mensah et al., 2015)

Buffy^UAS.cQa, Scer\GAL4^e22c is a suppressor of increased cell death phenotype of Scer\GAL4^e22c, hppy^UAS.cLa

(Lam et al., 2010)

Buffy^UAS.cQa/Scer\GAL4^ppk.1.9 is a suppressor of abnormal neuroanatomy | somatic clone phenotype of prel¹

(Tsubouchi et al., 2009)

Buffy^UAS.cQa, Scer\GAL4^ppk.1.9 is a suppressor of abnormal neuroanatomy | somatic clone phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^ppk.1.9

(Tsubouchi et al., 2009)

Buffy^UAS.cQa/Scer\GAL4^GMR.PF is a suppressor of increased cell death phenotype of Diap1⁵

(Quinn et al., 2003)

NOT Suppressor of

Statement

Reference

Buffy^UAS.cQa, Scer\GAL4^GMR.PFa is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Scer\GAL4^ey-OK107/Buffy^UAS.cQa is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype of bsk^flp147E

(Rallis et al., 2013)

Buffy^UAS.cQa/Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Ras85D^KP

(Wu et al., 2009)

Buffy^UAS.cQa/Scer\GAL4^hs.PB is a non-suppressor of abnormal flight phenotype of Pink1^B9

(Park et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

Buffy^UAS.cQa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Pi3K59F^KK107602, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^GMR.PU is an enhancer of ommatidium phenotype of Pi3K59F^KK107602, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Atg6^GD11647, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^GMR.PU is an enhancer of ommatidium phenotype of Atg6^GD11647, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Buffy^UAS.cQa, Scer\GAL4^GMR.PF is an enhancer of retina phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Buffy^UAS.cQa, Scer\GAL4^GMR.PF is an enhancer of pigment granule phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

NOT Enhancer of

Statement

Reference

Buffy^UAS.cQa, Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Buffy^UAS.cQa, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Dronc^UAS.EGFP, Scer\GAL4^GMR.PF

(Quinn et al., 2003)

Suppressor of

Statement

Reference

Buffy^UAS.cQa, Scer\GAL4^GMR.PF is a suppressor | partially of ommatidium phenotype of MICU1^GD4927, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, park^RNAi.UAS

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^GMR.PF is a suppressor of ommatidium | adult stage phenotype of Scer\GAL4^GMR.PF, park^RNAi.UAS

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of eye phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of eye phenotype of Lfg^KK104535, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of eye phenotype of Lfg^HMS00225, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^ppk.1.9 is a suppressor of dendrite & dorsal multidendritic neuron ddaC | somatic clone phenotype of prel¹

(Tsubouchi et al., 2009)

Buffy^UAS.cQa, Scer\GAL4^ppk.1.9 is a suppressor of larval dorsal multidendritic neuron ddaC | somatic clone phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^ppk.1.9

(Tsubouchi et al., 2009)

Buffy^UAS.cQa, Scer\GAL4^ppk.1.9 is a suppressor of mitochondrion & dorsal multidendritic neuron ddaC phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^ppk.1.9

(Tsubouchi et al., 2009)

Buffy^UAS.cQa/Scer\GAL4^hs.PB is a suppressor | partially of wing phenotype of Pink1^B9

(Park et al., 2006)

Buffy^UAS.cQa/Scer\GAL4^hs.PB is a suppressor | partially of adult thorax phenotype of Pink1^B9

(Park et al., 2006)

Buffy^UAS.cQa/Scer\GAL4^hs.PB is a suppressor | partially of mitochondrion phenotype of Pink1^B9

(Park et al., 2006)

Buffy^UAS.cQa/Scer\GAL4^hs.PB is a suppressor | partially of indirect flight muscle cell phenotype of Pink1^B9

(Park et al., 2006)

Buffy^UAS.cQa/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of hid^GMR.PG

(Quinn et al., 2003)

Buffy^UAS.cQa/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of grim^GMR.PC

(Quinn et al., 2003)

Buffy^UAS.cQa/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of rpr^GMR.PH

(Quinn et al., 2003)

Buffy^UAS.cQa, Scer\GAL4^en-e16E is a suppressor of wing phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^en-e16E

(Quinn et al., 2003)

NOT Suppressor of

Statement

Reference

Buffy^UAS.cQa, Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Scer\GAL4^ey-OK107/Buffy^UAS.cQa is a non-suppressor of alpha/beta Kenyon cell phenotype of bsk^flp147E

(Rallis et al., 2013)

Scer\GAL4^ey-OK107/Buffy^UAS.cQa is a non-suppressor of gamma Kenyon cell phenotype of bsk^flp147E

(Rallis et al., 2013)

Buffy^UAS.cQa/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Ras85D^KP

(Wu et al., 2009)

Buffy^UAS.cQa, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Dronc^UAS.EGFP, Scer\GAL4^GMR.PF

(Quinn et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Buffy^UAS.cQa enhances the reduced adult lifespan along with the impaired climbing ability of flies park^dsRNA.UAS under the control of Scer\GAL4^Ddc.PL, whereas it ameliorates the same phenotype in Pink1^dsRNA.UAS-expressing flies. The disrupted ommatidial lattice and loss of ommatidia of adult flies expressing park^dsRNA.UAS driven by Scer\GAL4^GMR.PF is ameliorated by Buffy^UAS.cQa, while flies expressing either Pink1^dsRNA.UAS or Buffy^UAS.cQa or both simultaneously under Scer\GAL4^GMR.PF do not show any eye morphology defects.

(M'Angale and Staveley, 2017)

The co-expression of Buffy^Scer\UAS.cQa suppresses the ommatidial defects (i.e ommatidial number and ommatidial array organization ) induced by the expression of either Pi3K59F^KK107602 or Atg6^GD11647 under the control of Scer\GAL4^GMR.PU.

(M'Angale and Staveley, 2016)

The reduced lifespan and impaired climbing ability characteristic for adult flies expressing either Lfg^KK104535 or Lfg^HMS00225 under the Scer\GAL4^Ddc.PL driver as well as the loss of ommatidia observed upon Scer\GAL4^GMR.PF-driven RNAi expression are suppressed by co-expression of Buffy^Scer\UAS.cQa.

(M'Angale and Staveley, 2016)

The shortened lifespan and poor climbing ability characteristic for adult flies expressing Debcl^{Scer\UAS.T:Ivir\HA1} (with the Scer\GAL4^Ddc.PL driver) as well as the eye morphological defects and loss of ommatidia (using the Scer\GAL4^GMR.PF driver) is much improved by co-expression of Buffy^Scer\UAS.cQa.

The morphology and number of ommatidia in the eyes of adult flies expressing both Debcl^JF02429 and Buffy^Scer\UAS.cQa simultaneously under the control of Scer\GAL4^GMR.PF is comparable to controls.

(M'Angale and Staveley, 2016)

Expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

(Rallis et al., 2013)

Ectopic caspase activation in the posterior compartment of the developing wing discs resulting from expression of hppy^Scer\UAS.cLa under the control of Scer\GAL4^e22c is moderately suppressed through co-expression of Buffy^Scer\UAS.cQa.

(Lam et al., 2010)

Co-expression of Buffy^Scer\UAS.cQa suppresses the mutant phenotype that is seen in the dendritic arbor of ddaC neuron clones expressing debcl^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ppk.1.9.

Co-expression of Buffy^Scer\UAS.cQa suppresses the altered mitochondrial distribution seen in ddaC neurons expressing debcl^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ppk.1.9.

Expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^ppk.1.9 suppresses the abnormal morphology of the dendritic arbors of prel¹ homozygous ddaC neuron clones.

(Tsubouchi et al., 2009)

The eye phenotype in Ras85D^KP mutant flies is not suppressed by ectopic expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^GMR.PF.

(Wu et al., 2009)

Expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^hs.PB markedly suppresses the adult wing and thorax phenotypes seen in Pink1^B9 flies. The indirect flight muscle defects are also suppressed in these animals, although the flight defect is not rescued.

(Park et al., 2006)

Xenogenetic Interactions

Statement

Reference

Co-expression of Buffy^Scer\UAS.cQa suppresses shortened lifespan and impaired climbing ability in flies with expression of Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^Ddc.PL. Co-expression of Buffy^Scer\UAS.cQa suppresses the rough eye phenotype seen in flies with expression of Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^GMR.PU.

(M'Angale and Staveley, 2016)

Co-expression of Buffy^Scer\UAS.cQa enhances the Scer\GAL4^GMR.PF; Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}-induced eye neurodegeneration and lethality. Eyes coexpressing Debcl^{Scer\UAS.T:Ivir\HA1}, Buffy^Scer\UAS.cQa, and Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} (all driven by Scer\GAL4^GMR.PF) show a significantly weaker degenerative eye phenotype than eyes expressing Buffy^Scer\UAS.cQa and Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}. Co-expression of Buffy^Scer\UAS.cQa enhances the decreased lifespan induced by the expression Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155.

(Senoo-Matsuda et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58358

w^*; P{UAS-Buffy.Q}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Buffy^Scer\UAS.cQa

Buffy^UAS.cQa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Quinn

(Quinn et al., 2003)

Secondary FlyBase IDs

References (21)

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