FlyBase Allele Report: Dmel\bsk[flp147E]

General Information

Symbol

Dmel\bsk^flp147E

Species

D. melanogaster

Name

FlyBase ID

FBal0057730

Feature type

allele

Associated gene

Dmel\bsk

Associated Insertion(s)

Carried in Construct

Also Known As

bsk^147e

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Riesgo-Escovar et al., 1996)

Mutagen

P-element activity

(Bohni et al., 1999, Riesgo-Escovar et al., 1996)

Progenitor genotype

P{ry11}chico¹

(Bohni et al., 1999)

chico¹

(Riesgo-Escovar et al., 1996)

Caused by aberration

Df(2L)flp147E

Cytology

Description

This is an imprecise excision of the P-element from chico¹. The 3'coding sequences are removed.

(Bohni et al., 1999)

Breaks in the bsk transcription unit, removing most of the bsk coding sequence including the kinase domain.

(Riesgo-Escovar et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | progressive | somatic clone

(Rallis et al., 2013)

abnormal neuroanatomy | pupal stage | somatic clone

(Rallis et al., 2010)

lethal - all die during embryonic stage

(Riesgo-Escovar et al., 1996)

some die during embryonic stage

(Riesgo-Escovar et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies containing bsk^flp147E mutant neuroblast clones show some β and γ mushroom body axon degeneration at 5 days post-eclosion, although most axons are still visible. This phenotype worsens in 28 day and 50 day old flies. A greater proportion of axons in bsk^flp147E mutant single cell γ cell clones show a "dying back" phenotype, in which they fail to reach the wild type termination point. Age matched wild type controls show no degeneration. bsk^flp147E mutant axons show more abnormal protrusions and swellings along the axons and terminals.

(Rallis et al., 2013)

The majority of bsk^flp147E neuroblast clones in mushroom bodies have axons with normal projections in early stages of pupal development, but the following defects are seen from 30 hours after puparium formation: most bsk^flp147E axons fail to reach the wild type termination point, bsk^flp147E clones show discontinuous thinning along the axon tracts, and the entire axon lobe is often missing by the adult stage.

In single cell bsk^flp147E clones, many mushroom body neurons have fully extended axons that show thinning and breaks. Such degeneration is also seen in the main process close to the cell body.

(Rallis et al., 2010)

Dorsal closure arrests early in some homozygous embryos, but dorsal closure manages to proceed further in a high percentage of the mutant embryos, sometimes even up to the zippering stage. In those mutant embryos that have a severe phenotype (little or no dorsalward net displacement and no straightening of the leading edge occurs), amnioserosa cell pulsations are sustained without damping. In embryos that manage to initiate dorsal closure, this usually happens with a significant time delay. With the onset of dorsalward leading edge movement, the leading edge begins to straighten in a manner similar to that of the wild-type but with much slower kinetics. In these mutant embryos, the damping of the amnioserosa cell pulsation also starts with a delay and is slower and parallels the behaviour of the leading edge.

(Solon et al., 2009)

bsk^flp147E clones generated along the A/P boundary of the wing imaginal disc, using the FLP/FRT technique, show no defects in segregation behaviour. As with wild-type clones, bsk^flp147E clones stay in the compartment (anterior or posterior) in which they have been generated.

(Shen and Dahmann, 2005)

Homozygous clones in the wing disc are recovered at high frequency. Homozygous clones in the pseudostratified epithelium of late-third instar wing discs have a normal shape and the actin and microtubule cytoskeletons are normal in cells of the clone.

(Shen and Dahmann, 2005)

When homozygous mutant somatic clones are made in the developing eye, a significant loss of photoreceptors and disordered ommatidia are seen.

(Strutt et al., 2002)

Embryos fail to show complete elongation of the dorsal epidermis after germband retraction.

(Ricos et al., 1999)

Initial phases of dorsal closure are normal, but the first rows under the leading cell row of the dorsal edge show only a partial lengthening cell shape change or no cell shape change at all. The defect is more pronounced in anterior cells. Homozygous clones in the eye reveal no abnormality.

(Riesgo-Escovar et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

bsk^flp147E has abnormal neuroanatomy | somatic clone | progressive phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Wld^{S.UAS.Tag:MYC}

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Nmnat1^UAS.Tag:MYC

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Nmnat3^UAS.Tag:MYC

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Wld^{S-dead.UAS.Tag:MYC}

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, suppressible by Scer\GAL4^ey-OK107/Hsap\HSPA1L^UAS.cWa

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, suppressible by Scer\GAL4^ey-OK107/Hsp26^UAS.Tag:HA

(Rallis et al., 2013)

NOT suppressed by

Statement

Reference

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by zip^ΔHD.UAS.YFP/Scer\GAL4^ey-OK107

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/Diap1^UAS.cHa

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/Diap2^UAS.cLa

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/Dronc^ΔN.C-A.UAS

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/Buffy^UAS.cQa

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/mTor^{WT.UAS.Tag:FLAG}

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/HDAC6^UAS.Tag:V5

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/Thor^UAS.cMa

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/park^UAS.cGa

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/Mmus\Nmnat2^UAS.Tag:MYC

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, non-suppressible by Scer\GAL4^ey-OK107/Scer\UBP2^UAS.cDa

(Rallis et al., 2013)

bsk^flp147E has abnormal neuroanatomy | somatic clone | progressive phenotype, non-suppressible by EcR^{B1-ΔC655.W650A.UAS}/Scer\GAL4^ey-OK107

(Rallis et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

bsk^flp147E has alpha/beta Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Wld^{S.UAS.Tag:MYC}

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Wld^{S.UAS.Tag:MYC}

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Nmnat1^UAS.Tag:MYC

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Nmnat1^UAS.Tag:MYC

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Nmnat3^UAS.Tag:MYC

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Nmnat3^UAS.Tag:MYC

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Wld^{S-dead.UAS.Tag:MYC}

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Mmus\Wld^{S-dead.UAS.Tag:MYC}

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Hsap\HSPA1L^UAS.cWa

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Hsap\HSPA1L^UAS.cWa

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Hsp26^UAS.Tag:HA

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, suppressible by Scer\GAL4^ey-OK107/Hsp26^UAS.Tag:HA

(Rallis et al., 2013)

NOT suppressed by

Statement

Reference

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by zip^ΔHD.UAS.YFP/Scer\GAL4^ey-OK107

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by zip^ΔHD.UAS.YFP/Scer\GAL4^ey-OK107

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/mTor^{WT.UAS.Tag:FLAG}

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/mTor^{WT.UAS.Tag:FLAG}

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/HDAC6^UAS.Tag:V5

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/HDAC6^UAS.Tag:V5

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Thor^UAS.cMa

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Thor^UAS.cMa

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/park^UAS.cGa

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/park^UAS.cGa

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Mmus\Nmnat2^UAS.Tag:MYC

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Mmus\Nmnat2^UAS.Tag:MYC

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Diap1^UAS.cHa

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Scer\UBP2^UAS.cDa

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Scer\UBP2^UAS.cDa

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Diap1^UAS.cHa

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by EcR^{B1-ΔC655.W650A.UAS}/Scer\GAL4^ey-OK107

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by EcR^{B1-ΔC655.W650A.UAS}/Scer\GAL4^ey-OK107

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Diap2^UAS.cLa

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Diap2^UAS.cLa

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Dronc^ΔN.C-A.UAS

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Dronc^ΔN.C-A.UAS

(Rallis et al., 2013)

bsk^flp147E has alpha/beta Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Buffy^UAS.cQa

(Rallis et al., 2013)

bsk^flp147E has gamma Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Buffy^UAS.cQa

(Rallis et al., 2013)

Suppressor of

Statement

Reference

bsk^flp147E/bsk[+] is a suppressor of scutum & macrochaeta phenotype of Rala^S25N.UAS, Scer\GAL4^sca-537.4

(Sawamoto et al., 1999)

Other

Statement

Reference

Mad^B1, bsk^flp147E has anterior-posterior compartment boundary of the wing disc | somatic clone phenotype

(Shen and Dahmann, 2005)

bsk^flp147E, tkv⁴ has anterior-posterior compartment boundary of the wing disc | somatic clone phenotype

(Shen and Dahmann, 2005)

bsk^flp147E, tkv⁴ has wing | somatic clone phenotype

(Shen and Dahmann, 2005)

bsk^flp147E, tkv⁴ has wing disc | somatic clone phenotype

(Shen and Dahmann, 2005)

bsk^flp147E, tkv⁴ has dorsal mesothoracic disc & actin filament | somatic clone phenotype

(Shen and Dahmann, 2005)

bsk^flp147E, tkv⁴ has dorsal mesothoracic disc & microtubule | apical | somatic clone phenotype

(Shen and Dahmann, 2005)

bsk^flp147E, msn[+]/msn¹⁰² has embryonic/first instar larval cuticle | dorsal phenotype

(Su et al., 1998)

bsk^flp147E/bsk[+], msn¹⁰² has embryonic/first instar larval cuticle | dorsal phenotype

(Su et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of EcR^{A-ΔC655.W650A.Scer\UAS} under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

Expression of zip^{ΔHD.Scer\UAS.T:Avic\GFP-YFP} under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

Expression of two copies of th^Scer\UAS.cHa under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

Expression of Iap2^Scer\UAS.cLa under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

Expression of two copies of Nc^{ΔN.C-A.Scer\UAS} under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

Expression of Buffy^Scer\UAS.cQa under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

Expression of Tor^{WT.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

Expression of HDAC6^{Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

Expression of Thor^Scer\UAS.cMa under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

Expression of park^Scer\UAS.cGa under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

(Rallis et al., 2013)

As tkv⁴ clones in the wing pouch do not survive due to apoptosis, and bsk^flp147E single mutant clones show no segregation defects in the wing, tkv⁴ bsk^flp147E clones can be used to study whether tkv⁴ affects segregation of cells at the A/P boundary. The majority of bsk^flp147E tkv⁴ clones of A origin in contact with the A/P boundary of the wing disc are misplaced into the P territory, causing a displacement of the A/P compartment boundary toward P. However, clones of P origin remain in the P compartment. The same defective segregation phenotype occurs in wing discs with Mad^B1 bsk^flp147E clones in contact with the A/P boundary.

(Shen and Dahmann, 2005)

The frequency of recovery of tkv⁴ bsk^flp147E double mutant clones (induced during the first larval instar) in the wing disc pouch of late-third instar larvae is only 24% compared to sibling wild-type clones, probably due to the formation of cyst-like structures followed by extrusion from the basal side of the epithelium. The double mutant clones are shorter along their apical-basal axis than normal, have lost contact to the apical epithelial surface and form cyst-like structures with the apical cell membranes facing the centre of the clone instead of the disc lumen. F-actin is enriched at the centre of the double mutant clones, whereas a dense apical network of microtubules, which is present in wild-type cells, is markedly reduced. Basal microtubules appear normal. Some tkv⁴ bsk^flp147E double mutant clones are seen in adult wings, as extruded cyst-like structures located between the dorsal and ventral wing surfaces. These mutant cells display hairs, characteristic structures of the adult epithelium, indicating that the extruded cells have undergone differentiation.

(Shen and Dahmann, 2005)

Df(2L)flp170B/Df(2L)flp147E animals in which the eyes are composed of homozygous Df(2L)flp170B clones (generated using the "eyFLP" system) and in which the deletion of bsk in Df(2L)flp170B and Df(2L)flp147E is rescued by the presence of bsk^+t5 have enlarged eyes, despite the reduced size of the structures around them. Other structures in the head and body that are unaffected by the eyFLP system appear to be maintained in proportion to the chico mutant body.

(Goberdhan and Wilson, 2002)

bsk^flp147E/+ msn¹⁰²/+ embryos have a dorsal open phenotype.

(Su et al., 1998)

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\wld^{S.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ey-OK107 suppresses the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones at both 5 and 28 days post-eclosion. The 'dying back' phenotype is also suppressed; clones generated in single γ cells show that axons are able to reach the wild type termination point. The number of enlarged and supernumerary axonal protrusions seen on bsk^flp147E mutant axon shafts is also significantly reduced.

Expression of Mmus\Nmnat1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ey-OK107 suppresses the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones at 28 days. The "dying back" phenotype is also suppressed; many of the axons now have wild type termination points. The number of enlarged and supernumerary axonal protrusions seen on bsk^flp147E mutant axon shafts is also significantly reduced.

Expression of Mmus\Nmnat2^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones at 28 days.

Expression of Mmus\Nmnat3^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ey-OK107 partially suppresses the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones at 28 days. The number of enlarged and supernumerary axonal protrusions seen on bsk^flp147E mutant axon shafts is also significantly reduced.

Expression of Mmus\wld^{S-dead.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ey-OK107 suppresses the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones at 28 days. The number of enlarged and supernumerary axonal protrusions seen on bsk^flp147E mutant axon shafts is also significantly reduced.

Expression of Hsap\HSPA1L^Scer\UAS.cWa under the control of Scer\GAL4^ey-OK107 partially suppresses the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones at 28 days. The number of enlarged and supernumerary axonal protrusions seen on bsk^flp147E mutant axon shafts is also significantly reduced.

Expression of Hsp26^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ey-OK107 partially suppresses the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones at 28 days.

Expression of Scer\UBP2^Scer\UAS.cDa under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

(Rallis et al., 2013)

Complementation and Rescue Data

Rescued by

bsk^flp147E is rescued by Scer\GAL4^ey-OK107/bsk^UAS.Tag:MYC

(Rallis et al., 2010)

Not rescued by

bsk^flp147E is not rescued by bsk^{mTPY.UAS.Tag:MYC}/Scer\GAL4^ey-OK107

(Rallis et al., 2010)

Comments

Expression of bsk^{mTPY.Scer\UAS.T:Hsap\MYC} using Scer\GAL4^ey-OK107 fails to rescue the axonal phenotypes seen in bsk^flp147E clones.

Expression of bsk^{Scer\UAS.T:Hsap\MYC} using Scer\GAL4^ey-OK107 rescues the axonal phenotypes seen in bsk^flp147E clones. bsk^{Scer\UAS.T:Hsap\MYC} needs to be provided throughout development to completely rescue.

(Rallis et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Cuticle phenotypes reveal an allelic series: bsk^J27 < bsk¹ < bsk² < bsk^flp147E.

(Riesgo-Escovar et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

bsk^-

(Shen and Dahmann, 2005)

bsk^147E

(Rallis et al., 2013, Rallis et al., 2010)

bsk^147e

(Rallis et al., 2010)

bsk^flp147E

(Zhu et al., 2019, Solon et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (17)

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