FB2026_03 , released September 17, 2026
Allele: Mmus\WldS.UAS.Tag:MYC
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General Information
Symbol
Mmus\WldS.UAS.Tag:MYC
Species
M. musculus
Name
FlyBase ID
FBal0288264
Feature type
allele
Associated gene
Mmus\Wld
Associated Insertion(s)
Carried in Construct
P{UAS-wld.S.MYC}
Also Known As
WldS::Myc
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Avery et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-wld.S.MYC}
Cytology
Description

UASt regulatory sequences drive expression of the fusion protein associated with the mouse 'Wld[S]' mutation. The fusion protein is composed of the N-terminal 70 amino acids of Mmus\Ube4b, a unique 18 amino acid domain generated during the fusion event and the full-length sequence of Mmus\Nmnat1. The fusion protein is tagged at the C-terminal end with 6xTag:MYC.

(Avery et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mmus\Wld
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Mmus\wldS.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ey-OK107 suppresses the axon degeneration seen in bskflp147E mutant mushroom body neuron clones at both 5 and 28 days post-eclosion. The 'dying back' phenotype is also suppressed; clones generated in single γ cells show that axons are able to reach the wild type termination point. The number of enlarged and supernumerary axonal protrusions seen on bskflp147E mutant axon shafts is also significantly reduced.

      (Rallis et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mmus\WldS.Scer\UAS.T:Hsap\MYC
      Mmus\WldS.UAS.Tag:MYC
      Mmus\wldS.Scer\UAS.T:Hsap\MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)