FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LfgHMS00225
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General Information
Symbol
Dmel\LfgHMS00225
Species
D. melanogaster
Name
FlyBase ID
FBal0257129
Feature type
allele
Associated gene
Dmel\Lfg
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS00225}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS00225}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS00225
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of LfgHMS00225 under the control of Scer\GAL4Ddc.PL results in decreased lifespan and impaired climbing ability in adult flies. Expression under the Scer\GAL4GMR.PF driver leads to loss of ommatidia and disruptions in the ommatidial lattice in the adult eye.

      (M'Angale and Staveley, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      LfgHMS00225, Scer\GAL4GMR.PF has eye phenotype, suppressible by BuffyUAS.cQa/Scer\GAL4Ddc.PL

      (M'Angale and Staveley, 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduced lifespan and impaired climbing ability characteristic for adult flies expressing LfgHMS00225 under the Scer\GAL4Ddc.PL driver as well as the loss of ommatidia observed upon Scer\GAL4GMR.PF-driven RNAi expression are suppressed by co-expression of BuffyScer\UAS.cQa.

      (M'Angale and Staveley, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG3814HMS00225
      LfgHMS00225
      Name Synonyms
      Secondary FlyBase IDs
        References (2)