FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\ATXN3CAG89.UAS.Tag:HA,Tag:MYC,Tag:polyHis
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General Information
Symbol
Hsap\ATXN3CAG89.UAS.Tag:HA,Tag:MYC,Tag:polyHis
Species
H. sapiens
Name
FlyBase ID
FBal0277779
Feature type
allele
Associated gene
Hsap\ATXN3
Associated Insertion(s)
Carried in Construct
P{UAS-ATXN3.CAG89.HAMycHis}
Key Links
Transgenic product class
trinucleotide_repeat_expansion
(Therrien and Rouleau, 2012.8.30)
Mutagen
Nature of the Allele
Transgenic product class
trinucleotide_repeat_expansion
(Therrien and Rouleau, 2012.8.30)
Mutagen
in vitro construct
(Therrien and Rouleau, 2012.8.30)
Progenitor genotype
Carried in construct
P{UAS-ATXN3.CAG89.HAMycHis}
Cytology
Description

UAS drives expression of Hsap\ATXN3 with an expanded stretch of 89 CAG repeats (similar to constructs found in FBrf0218121). At the C-terminus are tags for each reading frame: Tag:HA for the -1 frame, Tag:MYC for the main frame, and Tag:polyHis for the +1 frame.

(Therrien and Rouleau, 2012.8.30)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\ATXN3
Tagged with
Tag:HA
Tag:MYC
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Calpena et al., 2018)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is exacerbated by jpKK107921
      (Calpena et al., 2018)
      is ameliorated by jpUAS
      (Calpena et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Therrien and Rouleau, 2012.8.30)
      ATXN3:p.Gln296[89]
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      ATXN3:p.Gln296[89Gln]
      ATXN3, (CAG)n REPEAT EXPANSION
      Associated human disease model(s)
      External database links
      ClinVar: ATXN3_209995
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsap\ATXN3CAG89.Scer\UAS.T:Ivir\HA1,T:Hsap\MYC,T:Zzzz\His6 under the control of Scer\GAL4GMR.PU display progressive retinal degeneration resulting in patchy depigmentation of the adult eye in aged flies.

      (Calpena et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The age-progressive retinal degeneration manifested by patchy depigmentation of the adult eye characteristic for flies expressing Hsap\ATXN3CAG89.Scer\UAS.T:Ivir\HA1,T:Hsap\MYC,T:Zzzz\His6 under the control of Scer\GAL4GMR.PU is ameliorated by co-expression of jpUAS and exacerbated by co-expression of jpKK107921.

      (Calpena et al., 2018)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\ATXN3CAG89.Scer\UAS.T:Ivir\HA1,T:Hsap\MYC,T:Zzzz\His6
      Hsap\ATXN3CAG89.UAS.Tag:HA,Tag:MYC,Tag:polyHis
      Name Synonyms
      Secondary FlyBase IDs
        References (3)