FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Hsap\ATXN3, TER94
FlyBase ID
FBig0000116884
Interaction Network
Interactions Browser links
Hsap\ATXN3 network
TER94 network
Reported Interactions
FBrf0239190-1.PD.WB
Reference
Ristic et al., 2018
Description
physical association
Assay
Collection
Source/Stage
organism / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hsap\ATXN3 

Ataxin-3(SCA3)

bait

GST tag

Hsap\ATXN3 
TER94 

VCP

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Hsap\ATXN3 
VCP binding site
mutation decreasing interaction
aa 282-285

RKRR to HNHH

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from wild-type adult extract.

(Ristic et al., 2018)
FBrf0239190-2.coIP.WB
Reference
Ristic et al., 2018
Description
physical association
Assay
Collection
Source/Stage
head / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
TER94 

VCP

bait

HA tag

Hsap\ATXN3 

Ataxin-3(SCA3)

prey
Hsap\ATXN3 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Hsap\ATXN3 
VCP binding site
mutation disrupting interaction
aa 282-285

RKRR to HNHH

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult heads of transgenic fly line; bait produced from tagged transgenic construct; prey produced from tagged transgenic construct.

(Ristic et al., 2018)
FBrf0251804-1.coIP.WB
Reference
Johnson et al., 2021
Description
physical association
Assay
Collection
Source/Stage
adult head / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hsap\ATXN3 

ataxin-3

bait

HA tag

TER94 

TER94

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction reduced with the expression of pathogenic Hsap\ATXN3 (Q80)

(Johnson et al., 2021)

Source was adult heads of transgenic fly line; bait produced from transgenic construct; prey produced from endogenous gene.

(Johnson et al., 2021)
External Crossreferences and Linkouts ( 0 )
References (2)