FlyBase Allele Report: Dmel\Khc[9]

General Information

Symbol

Dmel\Khc⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0029881

Feature type

allele

Associated gene

Dmel\Khc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Saxton et al., 1991)

Progenitor genotype

Cytology

Description

Point mutation.

(Saxton et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}

(Gunawardena et al., 2003)

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Gunawardena et al., 2003)

modeled by htt^RNAi.UAS

(Gunawardena et al., 2003)

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Gunawardena et al., 2003)

modeled by Hsap\HTT^Q93.ex1.UAS

(Gunawardena et al., 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Saxton et al., 1991)

Phenotype Manifest In

Detailed Description

Statement

Reference

Larval growth abnormalities and lack of mobility.

(Saxton et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Khc⁹ is an enhancer of axon phenotype of Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}, Scer\GAL4^179Y

(Gunawardena et al., 2003)

Khc⁹ is an enhancer of axon phenotype of Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}, Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

Khc⁹ is an enhancer of axon phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

Khc⁹ is an enhancer of axon phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^179Y

(Gunawardena et al., 2003)

Khc[+]/Khc⁹ is an enhancer of axon | larval stage phenotype of Scer\GAL4^Appl.G1a, htt^RNAi.UAS

(Gunawardena et al., 2003)

Other

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Khc⁹, Scer\GAL4^179Y has axon | larval stage phenotype

(Gunawardena et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Khc⁹, Scer\GAL4^Appl.G1a has axon | larval stage phenotype

(Gunawardena et al., 2003)

Khc⁹, Scer\GAL4^179Y, Zzzz\CAG^{127Q.UAS.Tag:HA} has axon | larval stage phenotype

(Gunawardena et al., 2003)

Khc⁹, Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has axon | larval stage phenotype

(Gunawardena et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Khc⁹ is rescued by Khc^+t7.5

(Saxton et al., 1991)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

KHC^-

(Gunawardena et al., 2003)

Khc⁹

khc⁸

(Gunawardena et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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