FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\ATXN3ΔN'79QC.UAS.Tag:MYC
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General Information
Symbol
Hsap\ATXN3ΔN'79QC.UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0156381
Feature type
allele
Associated gene
Hsap\ATXN3
Associated Insertion(s)
Carried in Construct
P{UAS-ataxin-3.ΔN'79QC}
Key Links
Transgenic product class
inframe_deletion
(Matsumoto et al., 2004)
trinucleotide_repeat_expansion
(Matsumoto et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Matsumoto et al., 2004)
trinucleotide_repeat_expansion
(Matsumoto et al., 2004)
Mutagen
in vitro construct
(Matsumoto et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-ataxin-3.ΔN'79QC}
Cytology
Description

UASt regulatory sequences drive expression of an N-terminally deleted form of Hsap\ATXN3(79Q) (Hsap\ATXN3 with a polyglutamine tract of 79 residues) which lacks Hsap\ATXN3 residues 1-128 and is tagged with Tag:MYC.

(Matsumoto et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\ATXN3
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Matsumoto et al., 2004)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is ameliorated by Mmus\Ube4bUAS.Tag:FLAG
      (Matsumoto et al., 2004)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing Hsap\MJDΔN'79QC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.2sev have a disorganised external morphology of the eye. The arrangement of the photoreceptor cells is disrupted (the trapezoidal organisation of photoreceptors is almost completely absent).

      (Matsumoto et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Mmus\Ube4bScer\UAS.T:Zzzz\FLAG suppresses the pupal lethality caused by expression of Hsap\MJDΔN'79QC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF. Co-expression of Mmus\Ube4bScer\UAS.T:Zzzz\FLAG suppresses the eye phenotype caused by expression of Hsap\MJDΔN'79QC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.2sev.

      (Matsumoto et al., 2004)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\ATXN3ΔN'79QC.Scer\UAS.T:Hsap\MYC
      Hsap\ATXN3ΔN'79QC.UAS.Tag:MYC
      Hsap\MJDΔN'79QC.Scer\UAS.T:Hsap\MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)