FlyBase Allele Report: Hsap\ATXN1[82.UAS]

General Information

Symbol

Hsap\ATXN1^82.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0104777

Feature type

allele

Associated gene

Hsap\ATXN1

Associated Insertion(s)

Carried in Construct

P{UAS-Hsap\ATX1.82}

Also Known As

UAS-SCA1-82

Key Links

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Feany and Bender, 2000)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-Hsap\ATX1.82}

Cytology

Nature of the lesion

Statement

Reference

UAS regulatory sequences drive expression of mutant form of Hsap\ATXN1 which has an expanded repeat length encoding 82 glutamine residues.

(Feany and Bender, 2000)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\ATXN1

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal dominant cerebellar ataxia

CEA

(Ghosh and Feany, 2004)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of autosomal dominant cerebellar ataxia

is exacerbated by Hsc70-4^K71S.UAS

(Ghosh and Feany, 2004)

is exacerbated by Sirt1^EP2300

(Ghosh and Feany, 2004)

is ameliorated by BacA\p35^UAS.cUa

(Ghosh and Feany, 2004)

is exacerbated by Atx2^EP3145

(Ghosh and Feany, 2004, Shulman and Feany, 2003)

is exacerbated by Atx2^UAS.cSa

(Ghosh and Feany, 2004)

is ameliorated by DnaJ-1^UAS.cKa

(Ghosh and Feany, 2004)

is ameliorated by Diap1^UAS.cLa

(Ghosh and Feany, 2004)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Ghosh and Feany, 2004)

is exacerbated by pum^EP3461

(Ghosh and Feany, 2004)

is exacerbated by tara^EP3463

(Ghosh and Feany, 2004)

is exacerbated by CG7231^EP2510

(Ghosh and Feany, 2004, Shulman and Feany, 2003)

is ameliorated by Hsap\ATXN1L^{NBA.UAS.Tag:HA,Tag:NLS(Unk)}

(Mizutani et al., 2005)

is ameliorated by Hsap\ATXN1L^UAS.Tag:FLAG

(Mizutani et al., 2005)

is ameliorated by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}

(Warrick et al., 2005)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Feany and Bender, 2000)

ATXN1:p.Gln197[82]

(FlyBase curators, 2019-)

Variants Synonym(s)

ATXN1:p.Gln197[82Gln]

ATXN1, (CAG)n REPEAT EXPANSION

Associated human disease model(s)

spinocerebellar ataxia 1

External database links

ClinVar: ATXN1_8071

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal eye color, with Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

visible, with Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

adult brain, with Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

cholinergic neuron, with Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

eye, with Hsap\ATXN1^{0Q.UAS.Tag:FLAG}, Scer\GAL4^GMR.PF

(Mizutani et al., 2005)

eye, with Scer\GAL4^GMR.PF

(Mizutani et al., 2005, Tsai et al., 2004, Shulman and Feany, 2003)

eye photoreceptor cell, with Hsap\ATXN1^{0Q.UAS.Tag:FLAG}, Scer\GAL4^GMR.PF

(Mizutani et al., 2005)

eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Mizutani et al., 2005)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Mizutani et al., 2005, Tsai et al., 2004)

ommatidium, with Scer\GAL4^GMR.PF

(Mizutani et al., 2005, Tsai et al., 2004, Shulman and Feany, 2003)

pigment cell, with Scer\GAL4^GMR.PF

(Mizutani et al., 2005, Shulman and Feany, 2003)

retina, with Scer\GAL4^GMR.PF

(Warrick et al., 2005, Ghosh and Feany, 2004)

salivary gland, with Scer\GAL4^GMR.PF

(Tsai et al., 2004)

Detailed Description

Statement

Reference

Expression of Hsap\ATX1^82.Scer\UAS, under the control of Scer\GAL4^GMR.PF, results in a severely deformed eye phenotype. The ridge along the dorsal-ventral axis of the eye consistently displays the most severe defects; the eye surface is prominently glazed; there is a loss of bristles and pigmentation; ommatidia are disordered; photoreceptors suffer degeneration. Coexpression of Hsap\ATX1^82.Scer\UAS and Hsap\ATX1^{0Q.Scer\UAS.T:Zzzz\FLAG}, under the control of Scer\GAL4^GMR.PF, causes a more severe eye phenotype, in which eye structure is collapsed and photoreceptors are severely degenerated.

(Mizutani et al., 2005)

Flies expressing Hsap\ATX1^82.Scer\UAS under the control of Scer\GAL4^GMR.PF show severe disruption of the retinal structure.

(Warrick et al., 2005)

Expression of Hsap\ATX1^82.Scer\UAS under the control of Scer\GAL4^GMR.PF results in a retinal degeneration phenotype.

Expression of Hsap\ATX1^82.Scer\UAS under the control of Scer\GAL4^Cha.7.4 results in a brain degeneration phenotype, approximately 50% of cholinergic neurons of the lamina degenerate after 30 days.

(Ghosh and Feany, 2004)

When Hsap\ATX1^82.Scer\UAS is driven by Scer\GAL4^hs.PB (without heat shock) expression is seen in the salivary gland. This expression is detrimental to salivary gland development. Late third instar larvae display cellular deformations, including a significant reduction in cell volume and a notable disarray in tissue organisation. When Hsap\ATX1^82.Scer\UAS is driven by Scer\GAL4^GMR.PF a rough eye phenotype is seen.

(Tsai et al., 2004)

Expression of Hsap\ATX1^82.Scer\UAS under the control of Scer\GAL4^GMR.PF results in a slightly rough and depigmented eye.

(Shulman and Feany, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Atx2^EP3145, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by Atx2^EP3145, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Enhanced by

Statement

Reference

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP639^EP2437, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Orct2^EP3569, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Tao^EP1455, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG3735^EP2311, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Fem-1^EP2504, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Gbs-70E^EP3518, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP1072^EP1072/Orct2^EP1072, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP2190^EP2190, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Fmr1^EP3517, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by aop^EP2500, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by cdi^EP3319, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by chb^EP3403, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by cher^EP3715, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by dally^EP581, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by fry^EP326, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by garz^EP2028, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by par-1^EP899, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by stg^EP1213, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Diap1^EP3308, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by wdb^EP3559, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by wun^EP2208, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT suppressed by

Statement

Reference

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP639^EP2437, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Orct2^EP3569, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Tao^EP1455, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG3735^EP2311, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Fem-1^EP2504, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Gbs-70E^EP3518, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP1072^EP1072/Orct2^EP1072, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP2190^EP2190, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Fmr1^EP3517, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by aop^EP2500, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by cdi^EP3319, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by chb^EP3403, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by cher^EP3715, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by dally^EP581, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by fry^EP326, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by garz^EP2028, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by par-1^EP899, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by stg^EP1213, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Diap1^EP3308, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by wdb^EP3559, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by wun^EP2208, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Other

Statement

Reference

CG7231^EP2510, Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has lethal phenotype

(Ghosh and Feany, 2004)

Atx2^UAS.cSa, Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has lethal phenotype

(Ghosh and Feany, 2004)

Atx2^EP3145, Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has lethal phenotype

(Ghosh and Feany, 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Sirt1^EP2300, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by tara^EP3463, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by pum^EP3461, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Atx2^EP3145, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has interommatidial bristle phenotype, enhanceable by Smr^BG01648, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Tsai et al., 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by Smr^BG01648, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Tsai et al., 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Smr^BG01648, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Tsai et al., 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Atx2^EP3145, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has pigment cell phenotype, enhanceable by Atx2^EP3145, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has pigment cell phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Enhanced by

Statement

Reference

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, non-enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, non-enhanceable by Sirt1^EP2300, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, non-enhanceable by tara^EP3463, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, non-enhanceable by pum^EP3461, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by EP639^EP2437, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Orct2^EP3569, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Tao^EP1455, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG3735^EP2311, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Fem-1^EP2504, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Gbs-70E^EP3518, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by EP1072^EP1072/Orct2^EP1072, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by EP2190^EP2190, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Fmr1^EP3517, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by aop^EP2500, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by cdi^EP3319, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by chb^EP3403, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by cher^EP3715, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by dally^EP581, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by fry^EP326, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by garz^EP2028, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by par-1^EP899, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by stg^EP1213, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Diap1^EP3308, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by wdb^EP3559, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by wun^EP2208, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressed by

Statement

Reference

Hsap\ATXN1^82.UAS has pigment cell phenotype, suppressible by Hsap\ATXN1L^UAS.Tag:FLAG/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mizutani et al., 2005)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\ATXN1L^UAS.Tag:FLAG, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mizutani et al., 2005)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has interommatidial bristle phenotype, suppressible by Hsap\ATXN1L^UAS.Tag:FLAG, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mizutani et al., 2005)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Warrick et al., 2005)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by Diap1^UAS.cLa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, suppressible by Diap1^UAS.cLa, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Tsai et al., 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has interommatidial bristle phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Tsai et al., 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Tsai et al., 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Dp(1;Y)BSC5, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Tsai et al., 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has interommatidial bristle phenotype, suppressible by Dp(1;Y)BSC5, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Tsai et al., 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by Dp(1;Y)BSC5, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Tsai et al., 2004)

NOT suppressed by

Statement

Reference

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, non-suppressible by Hsc70-4^K71S.UAS, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, non-suppressible by Sirt1^EP2300, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, non-suppressible by tara^EP3463, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4 has adult brain phenotype, non-suppressible by pum^EP3461, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by EP639^EP2437, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Orct2^EP3569, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Tao^EP1455, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG3735^EP2311, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Fem-1^EP2504, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Gbs-70E^EP3518, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by EP1072^EP1072/Orct2^EP1072, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by EP2190^EP2190, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Fmr1^EP3517, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by aop^EP2500, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by cdi^EP3319, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by chb^EP3403, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by cher^EP3715, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by dally^EP581, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by fry^EP326, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by garz^EP2028, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by par-1^EP899, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by stg^EP1213, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Diap1^EP3308, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by wdb^EP3559, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by wun^EP2208, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Other

Statement

Reference

Hsap\ATXN1^82.UAS, Hsap\ATXN1L^UAS.Tag:FLAG, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has interommatidial bristle phenotype

(Mizutani et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of two copies of the Hsap\Boat^{Scer\UAS.T:Zzzz\FLAG} transgene, under the control of Scer\GAL4^GMR.PF, suppresses the Scer\GAL4^GMR.PF>Hsap\ATX1^82.Scer\UAS-induced eye phenotype. These flies show a restoration of bristle formation, pigmentation, and overall eye structure. However, there is also a gain-of-function phenotype, with rescued eyes showing thicker and longer bristles.

(Mizutani et al., 2005)

The retinal disruption seen in flies expressing Hsap\ATX1^82.Scer\UAS under the control of Scer\GAL4^GMR.PF is suppressed by co-expression of Hsap\MJD^{fl.Q27.Scer\UAS.T:Hsap\MYC}.

(Warrick et al., 2005)

The rough eye phenotype seen Hsap\ATX1^82.Scer\UAS, Scer\GAL4^GMR.PF animals is enhanced by Smr^BG01648, resulting in a glazed eye surface, severely disorganised ommatidia, and most prominently loss of bristles. The rough eye phenotype seen Hsap\ATX1^82.Scer\UAS, Scer\GAL4^GMR.PF animals is suppressed by Dp(1;Y)BSC5 or DnaJ-1^Scer\UAS.cKa.

(Tsai et al., 2004)

Co-expression of CG7231^EP2510 or Atx2^EP3145 enhances the eye phenotype caused by expression of Hsap\ATX1^82.Scer\UAS under the control of Scer\GAL4^GMR.PF; loss of eye pigmentation is enhanced and necrotic black spots are induced.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\ATX1^82.Scer\UAS

Hsap\ATXN1^82.Scer\UAS

Hsap\ATXN1^82.UAS

Name Synonyms

Secondary FlyBase IDs

References (7)

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