FlyBase Allele Report: Dmel\stg[EP1213]

General Information

Symbol

Dmel\stg^EP1213

Species

D. melanogaster

Name

FlyBase ID

FBal0119656

Feature type

allele

Associated gene

Dmel\stg

Associated Insertion(s)

P{EP}stg^EP1213

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bidet et al., 2003, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}stg^EP1213

Cytology

Description

P{EP} insertion 1628bp upstream of the stg translation initiation codon. The P{EP} element is oriented such that expression from the element should result in overexpression of stg.

(Bidet et al., 2003)

The orientation of the P{EP} element is the same as the direction of stg transcription.

(Shulman and Feany, 2003)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:29,256,557..29,256,557 [-]

(Bidet et al., 2003, Shulman and Feany, 2003, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

tormogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Detailed Description

Statement

Reference

Expression of stg^EP1213 under the control of Scer\GAL4^sca-537.4 results in potential shaft-to-socket transformations. Sensory organs with two sockets and two shafts, two sockets and one shaft and one socket and two shafts are seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^sca-537.4, stg^EP1213 has visible phenotype, non-enhanceable by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, stg^EP1213 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^sca-537.4, stg^EP1213 has visible phenotype, non-suppressible by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, stg^EP1213 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT Enhancer of

Statement

Reference

stg^EP1213, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

stg^EP1213, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Suppressor of

Statement

Reference

stg^EP1213, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

stg^EP1213, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

stg^EP1213/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

stg^EP1213/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Suppressor of

Statement

Reference

stg^EP1213, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

stg^EP1213, Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Suppressor of

Statement

Reference

stg^EP1213, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

stg^EP1213/Scer\GAL4^sca-537.4 is a non-suppressor of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by stg^EP1213.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

P{EP} insertion is approximately 1.5kb upstream of the stg transcription unit. However, it is not clear whether stg or a gene other than stg is affected in the P{EP}stg^EP1213 insertion line.

(Abdelilah-Seyfried et al., 2000)

Precise excision of the P{EP} element reverts the modifying effect of stg^EP1213 on the rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Shulman and Feany, 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EP(3)1213

(Abdelilah-Seyfried et al., 2000)

EP1213^EP1213

stg^EP1213

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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