FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gbs-70EEP3518
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General Information
Symbol
Dmel\Gbs-70EEP3518
Species
D. melanogaster
Name
FlyBase ID
FBal0156855
Feature type
allele
Associated gene
Dmel\Gbs-70E
Associated Insertion(s)
P{EP}Gbs-70EEP3518
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP}Gbs-70EEP3518
    Cytology
    Description

    The orientation of the P{EP} element is the same as the direction of CG9238 transcription.

    (Shulman and Feany, 2003)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP}
    Regulatory region(s)
    UAS
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  tauopathy
        modeled by Hsap\MAPTV337M.UAS
        (Shulman and Feany, 2003)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        CG9238EP3518 flies show a significant increase in locomotor activity upon repeated ethanol exposure compared to controls, with little or no effect on initial ethanol-induced hyperactivity, sedation sensitivity or sedation tolerance compared to controls.

        (Kong et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhancer of
        Statement
        Reference

        Gbs-70EEP3518, Scer\GAL4GMR.PF is a non-enhancer of visible phenotype of Hsap\ATXN182.UAS, Scer\GAL4GMR.PF

        (Shulman and Feany, 2003)
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        Gbs-70EEP3518, Scer\GAL4GMR.PF is a non-suppressor of visible phenotype of Hsap\ATXN182.UAS, Scer\GAL4GMR.PF

        (Shulman and Feany, 2003)
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        Gbs-70EEP3518, Scer\GAL4GMR.PF is a non-enhancer of eye phenotype of Hsap\ATXN182.UAS, Scer\GAL4GMR.PF

        (Shulman and Feany, 2003)
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        Gbs-70EEP3518, Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of Hsap\ATXN182.UAS, Scer\GAL4GMR.PF

        (Shulman and Feany, 2003)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        The rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is suppressed by CG9238EP3518.

        (Shulman and Feany, 2003)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Precise excision of the P{EP} element reverts the modifying effect of CG9238EP3518 on the rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF.

        (Shulman and Feany, 2003)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG9238EP3518
        EP3518
        (Kong et al., 2010)
        Gbs-70EEP3518
        Name Synonyms
        Secondary FlyBase IDs
          References (2)