FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
foxo, Hsap\ATXN3
FlyBase ID
FBig0000116992
Interaction Network
Interactions Browser links
foxo network
Hsap\ATXN3 network
Reported Interactions
FBrf0240610-1.coIP.WB
Reference
Kwon et al., 2018
Description
physical association
Assay
Collection
Source/Stage
head / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
foxo 

Foxo

bait

V5 or FLAG tag

foxo 
foxo 
Hsap\ATXN3 

MJD

prey

HA tag, 70 or 76 polyQ form

Hsap\ATXN3 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Hsap\ATXN3 
polyQ domain
mutation disrupting interaction

mutation of several Q residues to P, predicted to disrupt coiled-coil

foxo 
CC1 domain
mutation disrupting interaction
aa 429-449

mutation of several residues to G, predicted to disrupt coiled-coil

foxo 
CC2 domain
mutation disrupting interaction
aa 543-578

mutation of several residues to G, predicted to disrupt coiled-coil

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult heads of transgenic fly line; bait produced from tagged transgenic construct; prey produced from tagged transgenic construct.

(Kwon et al., 2018)
External Crossreferences and Linkouts ( 0 )
References (1)