FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Kap-α3UASp.cMa
Open Close
General Information
Symbol
Dmel\Kap-α3UASp.cMa
Species
D. melanogaster
Name
FlyBase ID
FBal0137474
Feature type
allele
Associated gene
Dmel\Kap-α3
Associated Insertion(s)
Carried in Construct
P{UASp-Kap-α3.M}
Key Links
Transgenic product class
wild_type
(Mason et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Mason et al., 2002)
Mutagen
in vitro construct
(Mason et al., 2002)
Progenitor genotype
Carried in construct
P{UASp-Kap-α3.M}
Cytology
Description

UASp regulatory sequences drive expression of Kap-α3. 22 nucleotides of the Kap-α3 5' UTR sequence and 42 nucleotides of the Kap-α3 3' UTR sequence are also present in the construct.

(Mason et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Kap-α3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Sowa et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Kap-α3UASp.cMa under the control of Scer\GAL4GMR.PF does not result to any obvious eye phenotypes compared to controls.

      (Sowa et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Kap-α3Scer\UAS.P\T.cMa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 does not rescue the sterility of PenD14 females.

      (Mason et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference

      The rough eye phenotype and associated depigmentation and necrosis induced by the expression of Hsap\ATXN3tr.Q78.UAS.Tag:HA under the control of Scer\GAL4GMR.PF are severely exacerbated by the co-expression of Kap-α3UASp.cMa, leading to prominent degeneration of the ommatidia. The late onset eye defects (i.e. disorganized ommatidia and tissue dissociation associated with the appearance of vacuoles) induced by the Scer\GAL4ninaE.PT-driven expression do not seem to be affected by the co-expression of Kap-α3UASp.cMa.

      The decreased lifespan and the decreased adult locomotion induced by the adulthood-only expression of Hsap\ATXN370Q.UAS under the control of Scer\GAL4elav.Switch.PO and RU-486 treatment are not significantly affected by the co-expression of Kap-α3UASp.cMa.

      (Sowa et al., 2018)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Kap-α3Scer\UAS.P\T.cMa
      Kap-α3UASp.cMa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)