FlyBase Allele Report: Dmel\Atx2[HMS02726]

General Information

Symbol

Dmel\Atx2^HMS02726

Species

D. melanogaster

Name

FlyBase ID

FBal0293367

Feature type

allele

Associated gene

Dmel\Atx2

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02726}

Also Known As

TRiP.HMS02726

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02726}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02726

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of spinocerebellar ataxia 2

CEA

(Del Castillo et al., 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{N548.Q128.UAS}

(Xu et al., 2019)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Xu et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Atx2^HMS02726 under the control of Scer\GAL4^P2.4.Pdf does not seem to have a major effect on circadian behavior, nor on the number of sLNv neurons in 10-days old adults.

(Xu et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Atx2^HMS02726, Scer\GAL4^P2.4.Pdf is a suppressor of abnormal circadian rhythm | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Atx2^HMS02726, Scer\GAL4^P2.4.Pdf is a suppressor | partially of abnormal circadian rhythm | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Atx2^HMS02726, Scer\GAL4^P2.4.Pdf is a suppressor | partially of abnormal circadian rhythm | adult stage phenotype of Hsap\HTT^{Q103.ex1p.UAS.EGFP}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

NOT Suppressor of

Statement

Reference

Atx2^HMS02726, Scer\GAL4^P2.4.Pdf is a non-suppressor of abnormal circadian rhythm | adult stage phenotype of Hsap\TARDBP^{A315T.UAS.RFP(Unk)}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Atx2^HMS02726, Scer\GAL4^P2.4.Pdf is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Atx2^HMS02726, Scer\GAL4^P2.4.Pdf is a non-suppressor of decreased cell number | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Scer\GAL4^P2.4.Pdf, Fmr1^HMS00248/Atx2^HMS02726 is a non-suppressor of abnormal circadian rhythm | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Fmr1^GL00075/Atx2^HMS02726, Scer\GAL4^P2.4.Pdf is a non-suppressor of abnormal circadian rhythm | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Scer\GAL4^Mef2.PR/Atx2^HMS02726 is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Scer\GAL4^Mef2.PR/Atx2^HMS02726 is a non-suppressor of flight muscle cell | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Atx2^HMS02726, Scer\GAL4^P2.4.Pdf is a non-suppressor of adult s-LNv neuron phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

44012

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02726}attP40

NIG-Fly

HMS02726

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02726}attP40/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Atx2^HMS02726

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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