FlyBase Allele Report: Dmel\Fmr1[GL00075]

General Information

Symbol

Dmel\Fmr1^GL00075

Species

D. melanogaster

Name

FlyBase ID

FBal0262561

Feature type

allele

Associated gene

Dmel\Fmr1

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00075}

Also Known As

UAS-dFMR1 RNAi, dfmr1 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00075}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00075

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of fragile X syndrome

CEA

(Song and Broadie, 2023, Song et al., 2022, Golovin et al., 2021, Vita et al., 2021, Sears et al., 2019, Greenblatt and Spradling, 2018, Kashima et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal recessive intellectual developmental disorder

modeled by Nab2^EP3716

(Bienkowski et al., 2017)

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q103.ex1p.UAS.EGFP}

(Xu et al., 2019)

modeled by Hsap\HTT^{N548.Q128.UAS}

(Xu et al., 2019)

modeled by Hsap\HTT^{Q72.ex1p.UAS.EGFP}

(Xu et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Fmr1^GL00075, Scer\GAL4^P2.4.Pdf is a suppressor of abnormal circadian rhythm | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Fmr1^GL00075, Scer\GAL4^P2.4.Pdf is a suppressor | partially of abnormal circadian rhythm | adult stage phenotype of Hsap\HTT^{Q103.ex1p.UAS.EGFP}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Fmr1^GL00075, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Bienkowski et al., 2017)

Fmr1^GL00075, Scer\GAL4^GMR.PU is a suppressor of abnormal eye color phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Bienkowski et al., 2017)

Fmr1^GL00075, Scer\GAL4^GMR.PU is a suppressor of abnormal size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Bienkowski et al., 2017)

NOT Suppressor of

Statement

Reference

Fmr1^GL00075, Scer\GAL4^P2.4.Pdf is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Fmr1^GL00075, Scer\GAL4^P2.4.Pdf is a non-suppressor of decreased cell number | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Fmr1^GL00075/Atx2^HMS02726, Scer\GAL4^P2.4.Pdf is a non-suppressor of abnormal circadian rhythm | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Fmr1^GL00075, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Bienkowski et al., 2017)

Fmr1^GL00075, Scer\GAL4^GMR.PU is a suppressor of ommatidium | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Bienkowski et al., 2017)

NOT Suppressor of

Statement

Reference

Fmr1^GL00075, Scer\GAL4^P2.4.Pdf is a non-suppressor of adult s-LNv neuron phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

The eye defects (reduced size, partial depigmentation and disorganization of the ommatidial lattice) characteristic for adult flies expressing Nab2^EP3716 under the control of Scer\GAL4^GMR.PU can be suppressed by co-expression of Fmr1^GL00075.

(Bienkowski et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

35200

y¹ sc^* v¹ sev²¹; P{TRiP.GL00075}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Fmr1^GL00075

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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