FlyBase Allele Report: Dmel\Fmr1[HMS00248]

General Information

Symbol

Dmel\Fmr1^HMS00248

Species

D. melanogaster

Name

FlyBase ID

FBal0263199

Feature type

allele

Associated gene

Dmel\Fmr1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00248}

Also Known As

UAS-dfmr1RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00248}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00248

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autism spectrum disorder

CEA

(Dong et al., 2016)

model of fragile X syndrome

CEA

(Greenblatt and Spradling, 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q103.ex1p.UAS.EGFP}

(Xu et al., 2019)

modeled by Hsap\HTT^{N548.Q128.UAS}

(Xu et al., 2019)

modeled by Hsap\HTT^{Q72.ex1p.UAS.EGFP}

(Xu et al., 2019)

ameliorates neurodegenerative disease

modeled by Zzzz\GGGGCC^48.UAS

(Schweizer Burguete et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dendrite | larval stage, with Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

dendritic branch | increased number | larval stage, with Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

larval multidendritic class IV neuron, with Scer\GAL4^ppk.PG

(Li and Gavis, 2022, Li and Gavis, 2022)

microtubule | larval stage, with Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

wing, with Scer\GAL4^nub-AC-62

(Yan and Perrimon, 2015)

Detailed Description

Statement

Reference

Flies expressing Fmr1^HMS00248 under the control of Scer\GAL4^ey-OK107, or under the control of Scer\GAL4^{Mef2.247.Switch} and feeding with RU486 to induce expression via the GeneSwitch system, do not exhibit defective learning in an aversive conditioning assay, but do exhibit defects in a reversal-learning paradigm, with a third-odor preference assay showing an inability to forget the first aversive odor association after training with a second aversive odor, as compared to controls.

(Dong et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Fmr1^HMS00248, Scer\GAL4^ppk.PG has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by chic²²¹

(Li and Gavis, 2022)

Fmr1^HMS00248, Scer\GAL4^ppk.PG has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by chic^HMS00550, Scer\GAL4^ppk.PG