FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NachJF02566
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General Information
Symbol
Dmel\NachJF02566
Species
D. melanogaster
Name
FlyBase ID
FBal0239267
Feature type
allele
Associated gene
Dmel\Nach
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02566}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.8.10)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.8.10)
Mutagen
in vitro construct
(Perkins et al., 2009.8.10)
Progenitor genotype
Carried in construct
P{TRiP.JF02566}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.8.10)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02566
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (McGurk and Bonini, 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of NachJF02566 under the control of Scer\GAL4Myo31DF-NP0001 does not affect the number of mitotic cells in the posterior midgut at 14 days post eclosion.

      (Kim et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      NachJF02566, Scer\GAL4GMR.PU is a non-suppressor of visible phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PU

      (McGurk and Bonini, 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The expression of NachJF02566 suppresses the increased number of mitotic cells in the adult posterior midgut exhibited by bftΔ263a/bftΔ263a-G4 transheterozygotes (expression under the control of Scer\GAL4bft-Δ263a-G4, the inherent Gal4 driver in the bftΔ263a-G4 alele, where it replaces the bft hairpin sequence) or bftΔ263a homozygotes (expression under the control of Scer\GAL4Myo31DF-NP0001); expression under the control of Scer\GAL4bft-Δ263a-G4 also suppresses the overall increase in the gut pH and the decreased thickness of the adult posterior midgut peritrophic matrix of bftΔ263a/bftΔ263a-G4 heterozygotes, even leading to its significant increase in thickness as compared to wild-type controls.

      (Kim et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      NachJF02566
      Name Synonyms
      Secondary FlyBase IDs
        References (6)