FlyBase Allele Report: Dmel\Mlf[UAS.cKa]

General Information

Symbol

Dmel\Mlf^UAS.cKa

Species

D. melanogaster

Name

FlyBase ID

FBal0213092

Feature type

allele

Associated gene

Dmel\Mlf

Associated Insertion(s)

Carried in Construct

P{UAS-Mlf.K}

Key Links

Transgenic product class

wild_type

(Martin-Lanneree et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Martin-Lanneree et al., 2006)

Mutagen

in vitro construct

(Martin-Lanneree et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Mlf.K}

Cytology

Description

UAS regulatory sequences drive expression of the Mlf-B isoform.

(Martin-Lanneree et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mlf

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Martin-Lanneree et al., 2006)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mlf^UAS.cKa, Scer\GAL4^{elav.Switch.PO} is a suppressor | partially of short lived | RU486 conditional phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^{elav.Switch.PO}

(Martin-Lanneree et al., 2006)

Mlf^UAS.cKa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Mlf^UAS.cKa, Scer\GAL4^Appl.G1a is a suppressor of lethal | larval stage phenotype of Scer\GAL4^Appl.G1a, Zzzz\CAG^{63Q.UAS.Tag:HA}

(Kazemi-Esfarjani and Benzer, 2002)

Mlf^UAS.cKa, Scer\GAL4^Appl.G1a is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^Appl.G1a, Zzzz\CAG^{63Q.UAS.Tag:HA}

(Kazemi-Esfarjani and Benzer, 2002)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mlf^UAS.cKa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Mlf^UAS.cKa, Scer\GAL4^GMR.PF is a suppressor of pigment cell phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Mlf^UAS.cKa, Scer\GAL4^Appl.G1a is a suppressor of eye phenotype of Scer\GAL4^Appl.G1a, Zzzz\CAG^{63Q.UAS.Tag:HA}

(Kazemi-Esfarjani and Benzer, 2002)

Mlf^UAS.cKa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Kazemi-Esfarjani and Benzer, 2002)

NOT Suppressor of

Statement

Reference

Mlf^UAS.cKa, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, pros^{127Q.UAS.Tag:HA}

(Kazemi-Esfarjani and Benzer, 2002)

Mlf^UAS.cKa, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PF

(Kazemi-Esfarjani and Benzer, 2002)

Other

Statement

Reference

Mlf^UAS.cKa, Scer\GAL4^GMR.PF, pros^{127Q.UAS.Tag:HA} has eye phenotype

(Kazemi-Esfarjani and Benzer, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Mlf^Scer\UAS.cKa results in a strong suppression of the mutant eye phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. The reduction in life span that is seen in flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^{elav.Switch.PO} in the presence of RU486 is partially rescued by co-expression of Mlf^Scer\UAS.cKa.

(Martin-Lanneree et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

31034

w¹¹¹⁸; P{UAS-Mlf.K}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mlf^Scer\UAS.cKa

Mlf^UAS.cKa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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