FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pros127Q.UAS.Tag:HA
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General Information
Symbol
Dmel\pros127Q.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0241462
Feature type
allele
Associated gene
Dmel\pros
Associated Insertion(s)
Carried in Construct
P{UAS-pros.127Q}
Key Links
Transgenic product class
inframe_deletion
(Kazemi-Esfarjani and Benzer, 2002)
trinucleotide_repeat_expansion
(Kazemi-Esfarjani and Benzer, 2002)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Kazemi-Esfarjani and Benzer, 2002)
trinucleotide_repeat_expansion
(Kazemi-Esfarjani and Benzer, 2002)
Mutagen
in vitro construct
(Kazemi-Esfarjani and Benzer, 2002)
Progenitor genotype
Carried in construct
P{UAS-pros.127Q}
Cytology
Description

UAS regulatory sequences drive expression of a C-terminal part of pros containing an expanded 127Q polyQ tract (a 20Q tract is found in the wild-type protein). The polyQ tract is flanked by 33 amino acids on the N-terminal side and by 369 amino acids on the C-terminal side. The protein is tagged at the C-terminal end with Tag:HA.

(Kazemi-Esfarjani and Benzer, 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
pros
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of prosZzzz\CAG.127Q.Scer\UAS.T:Ivir\HA1 in the developing eye under the control of Scer\GAL4GMR.PF results in disruption of eye structure and a lack of pigmentation (although the toxicity is less than in Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 mutants).

      (Kazemi-Esfarjani and Benzer, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Retina expressing MlfScer\UAS.cKa and prosZzzz\CAG.127Q.Scer\UAS.T:Ivir\HA1 both under the control of Scer\GAL4GMR.PF results in retinas that are thinner than wild-type and exhibit aberrant tissue morphology.

      The presence of one or two copies of MlfScer\UAS.cKa (with the Scer\GAL4GMR.PF driver) fails to suppress the deterioration of eye structure after 1 day post eclosion found in flies expressing prosZzzz\CAG.127Q.Scer\UAS.T:Ivir\HA1.

      Retina expressing Ecol\lacZScer\UAS.T:SV40\nls2 or Ecol\lacZScer\UAS.cBa with prosZzzz\CAG.127Q.Scer\UAS.T:Ivir\HA1, under the control of Scer\GAL4GMR.PF does not suppress the toxic effects of prosZzzz\CAG.127Q.Scer\UAS.T:Ivir\HA1 expression.

      (Kazemi-Esfarjani and Benzer, 2002)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      pros127Q.Scer\UAS.T:Ivir\HA1
      pros127Q.UAS.Tag:HA
      prosZzzz\CAG.127Q.Scer\UAS.T:Ivir\HA1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)