FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\cdmGS17666
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General Information
Symbol
Dmel\cdmGS17666
Species
D. melanogaster
Name
FlyBase ID
FBal0340191
Feature type
allele
Associated gene
Dmel\cdm
Associated Insertion(s)
P{GSV6}cdmGS17666
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV6}cdmGS17666
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV6}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  Machado-Joseph disease
        modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
        (Sowa et al., 2018)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The expression of cdmGS17666 under the control of Scer\GAL4drl-P15 leads to lethality during development. Expression under the control of Scer\GAL4GMR.PF does result in any obvious eye phenotypes compared to controls.

        (Sowa et al., 2018)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        cdmGS17666, Scer\GAL4GMR.PF is a suppressor of eye phenotype of Hsap\ATXN3tr.Q78.UAS.Tag:HA, Scer\GAL4GMR.PF

        (Sowa et al., 2018)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        The rough eye phenotype and associated depigmentation and necrosis induced by the expression of Hsap\ATXN3tr.Q78.UAS.Tag:HA under the control of Scer\GAL4GMR.PF are slightly improved by the co-expression of cdmGS17666.

        The decreased adult locomotion and decreased lifespan induced by the adulthood-only expression of Hsap\ATXN370Q.UAS under the control of Scer\GAL4elav.Switch.PO and RU-486 treatment are not significantly affected by the co-expression of cdmGS17666.

        (Sowa et al., 2018)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        cdmGS17666
        Name Synonyms
        Secondary FlyBase IDs
          References (1)