FB2026_02 , released June 18, 2026

CV Term Report

Help Close All Open All

General Information

Term

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

ID (Ontology)

GO:0000288 (Gene Ontology)

Definition

A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.

Also Known As

"deadenylation-dependent mRNA decay" ; "mRNA breakdown, deadenylation-dependent decay" ; "mRNA catabolic process, deadenylation-dependent" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (all annotations which use CV term, excluding "NOT" statements)
involved_in \| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Spanning Tree (Parents/Children)

mRNA catabolic process
 |__nuclear-transcribed mRNA catabolic process__
negative regulation of gene expression          |
 |__mRNA destabilization________________________|
regulation of mRNA stability                    |
 |__mRNA destabilization________________________|
RNA destabilization                             |
 |__mRNA destabilization________________________|
positive regulation of mRNA catabolic process   |
 |__mRNA destabilization________________________|
                                                nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  26 rec.
                                                 |__deadenylation-dependent decapping of nuclear-transcribed mRNA 7 rec.
                                                 |   |__regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA(+)
                                                 |__nuclear-transcribed mRNA poly(A) tail shortening 17 rec.
                                                 |   |__regulation of nuclear-transcribed mRNA poly(A) tail shortening(+) 6 rec.
                                                 |__regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2 rec.
                                                     |__negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(+)
                                                     |__positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	nuclear-transcribed mRNA catabolic process mRNA destabilization
Part of
Synonyms & Secondary IDs
Synonyms
	"deadenylation-dependent mRNA decay" EXACT "mRNA breakdown, deadenylation-dependent decay" EXACT "mRNA catabolic process, deadenylation-dependent" EXACT "mRNA catabolic process, deadenylylation-dependent" EXACT "mRNA catabolism, deadenylation-dependent" EXACT "mRNA catabolism, deadenylylation-dependent" EXACT "mRNA degradation, deadenylation-dependent decay" EXACT "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-429914 "Deadenylation-dependent mRNA decay"