FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term glutathione-disulfide reductase (NADPH) activity ID (Ontology) GO:0004362 (Gene Ontology)
Definition Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.[ PubMed:36771108 ]
Also Known As "glutathione reductase activity" ; "glutathione-disulfide reductase (NADP) activity" ; "glutathione-disulfide reductase activity" (for all, see Synonyms field below)
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 NOT | enables | glutathione-disulfide reductase (NADPH) activity       1
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molecular_function
 |__antioxidant activity_____________________________________________________________
disulfide oxidoreductase activity                                                    |
 |__glutathione disulfide oxidoreductase activity____________________________________|
oxidoreductase activity, acting on a sulfur group of donors                          |
 |__oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor__|
                                                                                     glutathione-disulfide reductase (NADPH) activity
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Is a glutathione disulfide oxidoreductase activity
antioxidant activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
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Synonyms
  • "glutathione reductase activity" EXACT
    "glutathione S-reductase activity" RELATED[ EC:1 ]
    "glutathione-disulfide reductase (NADP) activity" EXACT
    "glutathione-disulfide reductase activity" EXACT
    "glutathione-disulphide reductase activity" EXACT
    "glutathione:NADP+ oxidoreductase activity" RELATED[ EC:1 ]
    "GSH reductase activity" RELATED[ EC:1 ]
    "GSSG reductase activity" RELATED[ EC:1 ]
    "NADPH-glutathione reductase activity" RELATED[ EC:1 ]
    "NADPH-GSSG reductase activity" RELATED[ EC:1 ]
    "NADPH:oxidized-glutathione oxidoreductase activity" RELATED[ EC:1 ]
    "oxidized glutathione reduction" RELATED
Secondary IDs
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EC:1.8.1.7
MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN
Reactome:R-HSA-3323079 "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+"
Reactome:R-HSA-71682 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+"
RHEA:11740