FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term helicase activity ID (Ontology) GO:0004386 (Gene Ontology)
Definition Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
Also Known As "ATP-dependent helicase activity"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      30
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 helicase activity (all annotations which use CV term, excluding "NOT" statements)       1     30
     enables | helicase activity       --      30
 NOT | enables | helicase activity       --       1
Spanning Tree (Parents/Children)
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molecular_function
 |__ATP-dependent activity________________________
catalytic activity                                |
 |__catalytic activity, acting on a nucleic acid__|
macromolecular conformation isomerase activity    |
 |__nucleic acid conformation isomerase activity__|
                                                  helicase activity  100 rec.
                                                   |__DNA helicase activity 39 rec.
                                                   |   |__3'-5' DNA helicase activity(+) 15 rec.
                                                   |   |__5'-3' DNA helicase activity 4 rec.
                                                   |   |__double-stranded DNA helicase activity 2 rec.
                                                   |   |__forked DNA-dependent helicase activity
                                                   |   |__four-way junction helicase activity 5 rec.
                                                   |   |__single-stranded DNA helicase activity(+) 11 rec.
                                                   |__DNA/RNA helicase activity 2 rec.
                                                   |   |__3'-5' DNA/RNA helicase activity 1 rec.
                                                   |   |__5'-3' DNA/RNA helicase activity
                                                   |__RNA helicase activity 62 rec.
                                                       |__3'-5' RNA helicase activity 4 rec.
                                                       |__5'-3' RNA helicase activity 4 rec.
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Is a nucleic acid conformation isomerase activity
catalytic activity, acting on a nucleic acid
ATP-dependent activity
Part of
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Synonyms
  • "ATP-dependent helicase activity" EXACT
Secondary IDs
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Reactome:R-HSA-169461 "MCM8 mediated fork unwinding"
Reactome:R-HSA-169468 "MCM2-7 mediated fork unwinding"
Reactome:R-HSA-5686410 "BLM mediates dissolution of double Holliday junction"
Reactome:R-HSA-5690996 "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA"