FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term methylenetetrahydrofolate reductase [NAD(P)H] activity ID (Ontology) GO:0004489 (Gene Ontology)
Definition Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.[ EC:1 PubMed:26872964 ]
Also Known As "5,10-methylenetetrahydrofolate reductase (FADH) activity" ; "5,10-methylenetetrahydrofolate reductase (FADH2) activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 methylenetetrahydrofolate reductase [NAD(P)H] activity (all annotations which use CV term, excluding "NOT" statements)
     enables | methylenetetrahydrofolate reductase [NAD(P)H] activity
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  oxidoreductase activity, acting on the CH-NH group of donors
   |__oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
       |__methylenetetrahydrofolate reductase [NAD(P)H] activity  1 rec.
           |__methylenetetrahydrofolate reductase (NADH) activity
           |__methylenetetrahydrofolate reductase (NADPH) activity 1 rec.
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Is a oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
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Synonyms
  • "5,10-CH(2)-H(4)folate reductase activity" RELATED[ EC:1 ]
    "5,10-CH2-H4folate reductase activity" RELATED[ EC:1 ]
    "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED[ EC:1 ]
    "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT
    "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT
    "5,10-methylenetetrahydrofolate reductase (NADPH) activity" RELATED[ EC:1 ]
    "5,10-methylenetetrahydrofolate reductase activity" BROAD[ EC:1 ]
    "5,10-methylenetetrahydrofolic acid reductase activity" BROAD[ EC:1 ]
    "5,10-methylenetetrahydropteroylglutamate reductase activity" RELATED[ EC:1 ]
    "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" RELATED[ EC:1 ]
    "5-methyltetrahydrofolate:NAD oxidoreductase activity" RELATED[ EC:1 ]
    "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" RELATED[ EC:1 ]
    "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" RELATED[ EC:1 ]
    "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" RELATED[ EC:1 ]
    "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" RELATED[ EC:1 ]
    "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" RELATED[ EC:1 ]
    "MetF" RELATED[ EC:1 ]
    "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED[ EC:1 ]
    "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED[ EC:1 ]
    "methylenetetrahydrofolate reductase (NADPH(2)) activity" RELATED[ EC:1 ]
    "methylenetetrahydrofolate reductase (NADPH2)" RELATED[ EC:1 ]
    "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED[ EC:1 ]
    "methylenetetrahydrofolate reductase activity" BROAD[ EC:1 ]
    "methylenetetrahydrofolic acid reductase activity" BROAD[ EC:1 ]
    "MTHFR activity" BROAD[ EC:1 ]
    "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD[ EC:1 ]
    "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD[ EC:1 ]
    "N5,10-methylenetetrahydrofolate reductase activity" RELATED[ EC:1 ]
    "N5,N10-methylenetetrahydrofolate reductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.5.1.20
KEGG_REACTION:R01224
KEGG_REACTION:R07168
MetaCyc:1.5.1.20-RXN
Reactome:R-HSA-200676 "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG"