FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term Rab geranylgeranyltransferase activity ID (Ontology) GO:0004663 (Gene Ontology)
Definition Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.[ EC:2 PubMed:8621375 ]
Also Known As"geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" ; "GGTase-II activity" ; "GGTaseII activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 Rab geranylgeranyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | Rab geranylgeranyltransferase activity
     enables | Rab geranylgeranyltransferase activity
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  protein prenyltransferase activity
   |__protein geranylgeranyltransferase activity
       |__Rab geranylgeranyltransferase activity  3 rec.
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Is a protein geranylgeranyltransferase activity
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Synonyms
  • "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT
    "GGTase-II activity" EXACT
    "GGTaseII activity" EXACT
    "protein geranylgeranyltransferase type II activity" EXACT
    "Rab-protein geranylgeranyltransferase activity" EXACT
    "RabGGTase activity" EXACT
    "type II protein geranyl-geranyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.5.1.60
MetaCyc:RXN-19995
MetaCyc:RXN-19996
MetaCyc:RXN-19997